D E P A R T M E N T S:

GUEST EDITORIAL:

Controlled Clinical Trials and Practice-based Research in Dentistry

Ivar A. Mjör
The author emphasizes the importance of differentiating controlled clinical trials and practice-based dental research in dental curricula and continuing dental education.

J Dent Res 2008 87: 605. [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Self-assembling Peptides: From Bio-inspired Materials to Bone Regeneration

C. E. Semino
The author describes the discovery, properties, and development of self-assembling peptides to be used as three-dimensional scaffolds, based on their similarity (in structure and mechanical features) to extracellular matrices.

J Dent Res 2008 87: 606-616. [Abstract] [Full Text] [Figures Only] [PDF]  

Tooth Agenesis: from Molecular Genetics to Molecular Dentistry

E. Matalova, J. Fleischmannova, P.T. Sharpe, and A.S. Tucker
The authors review the genetic and molecular bases of non-syndromic and syndromic hypodontia, and discuss the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis.

J Dent Res 2008 87: 617-623. [Abstract] [Full Text] [Figures Only] [PDF]  

RAPID COMMUNICATION:

Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets

L. Ye, S. Zhang, H. Ke, L. F. Bonewald, and JQ. Feng
Defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice.

J Dent Res 2008 87: 624-629. [Abstract] [Full Text] [Figures Only] [PDF] Appendix  

R E S E A R C H  R E P O R T S:

Clinical:

Salivary Procalcitonin and Periodontitis in Diabetes

C.W. Bassim, R.S. Redman, D.J. DeNucci, K.L. Becker, and E.S. Nylen
This study demonstrates, for the first time, the presence of procalcitonin, an established serum marker of infection, in saliva.

J Dent Res 2008 87: 630-634. [Abstract] [Full Text] [Figures Only] [PDF]  

Randomized Study of Phentolamine Mesylate for Reversal of Local Anesthesia

M. Laviola, S.K. McGavin, G.A. Freer, G. Plancich, S.C. Woodbury, S. Marinkovich, R. Morrison, A. Reader, R.B. Rutherford, and J.A. Yagiela
The authors tested the hypothesis that local injection of the vasodilator phentolamine mesylate would shorten the duration of soft-tissue anesthesia following routine dental procedures.

J Dent Res 2008 87: 635-639. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Changing Clinicians’ Behavior: a Randomized Controlled Trial of Fees and Education

J.E. Clarkson, S. Turner, J.M. Grimshaw, C.R. Ramsay, M. Johnston, A. Scott, D. Bonetti, C.J. Tilley, G. Maclennan, R. Ibbetson, L.M.D. MacPherson, and N.B. Pitts
This was the first experimental study in primary dental care to use a rigorous design to compare the effectiveness of fee-for-service and educational interventions in promoting evidence-based practice, and led to the introduction of a direct fee for fissure-sealing.

J Dent Res 2008 87: 640-644. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Biomaterials & Bioengineering:

Compositional Determinants of Mechanical Properties of Enamel

M. Baldassarri, H.C. Margolis, and E. Beniash
This is the first direct observation of the effect of organic matrix on the mechanical properties of enamel, which could help guide the development of bio-inspired nanostructured materials for mineralized tissue repair and regeneration.

J Dent Res 2008 87: 645-649. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Proliferation and Differentiation of MC3T3-E1 Cells on Calcium Phosphate/Chitosan Coatings

J. Wang, J. de Boer, and K. de Groot
This is the first report of the reactions of osteoblasts on electrodeposited CaP and CaP/chitosan coatings.

J Dent Res 2008 87: 650-654. [Abstract] [Full Text] [Figures Only] [PDF]  

Changes in Resin-infiltrated Dentin Stiffness after Water Storage

S. Chiaraputt, S. Mai, B.P. Huffman, R. Kapur, K.A. Agee, C.K.Y. Yiu, D.C.N. Chan, C. Harnirattisai, D.D. Arola, F.A. Rueggeberg, D.H. Pashley, and F.R. Tay
The authors tested the hypothesis that when adhesive resins were used to create resin-infiltrated dentin, the reductions in their flexural moduli after water storage would be lowered proportional to their hydrophilic characteristics.

J Dent Res 2008 87: 655-660. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Analysis of the Degradation of a Model Dental Composite

P.J. Koin, A. Kilislioglu, M. Zhou, J.L. Drummond, and L. Hanley
The authors studied degradation of dental composites in a simplified overlayer model in which bisphenol A diglycidyl methacrylate was covalently bound to a porous silicon oxide surface.

J Dent Res 2008 87: 661-665. [Abstract] [Full Text] [Figures Only] [PDF]  

Cooperation of Phosphate Monomer and Silica Modification on Zirconia

R. Tanaka, A. Fujishima, Y. Shibata, A. Manabe, and T. Miyazaki
The application of MDP monomer with a silane coupling agent on silica-coated YPSZ ceramics by tribochemical modification is a promising method for ceramic restorations in clinical settings.

J Dent Res 2008 87: 666-670. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Damage Maps for Layered Ceramics under Simulated Mastication

J.-H. Kim, J.-W. Kim, S.-W. Myoung, M. Pines, and Y. Zhang
The authors investigated the influence of off-axis fatigue loading on the crack modes and fatigue life of brittle layer structures, using a hard sphere on glass/polycarbonate bilayers as a model system.

J Dent Res 2008 87: 671-675. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Biological:

Characterization of Dental Pulp Stem Cells of Human Tooth Germs

T. Takeda, Y. Tezuka, M. Horiuchi, K. Hosono, K. Iida, D. Hatakeyama, S. Miyaki, T. Kunisada, T. Shibata, and K. Tezuka
The authors characterized human dental pulp stem cells isolated from an earlier developmental stage to evaluate their potential for tissue-regenerative therapy.

J Dent Res 2008 87: 676-681. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Synergism between TLRs and NOD1/2 in Oral Epithelial Cells

A. Uehara and H. Takada
This is the first report that the intracellular receptors NOD1 and 2 have synergistic effects with Toll-like receptor agonists, as well as TLR4-agonistic lipid A, to induce the production of an antimicrobial peptide in human epithelial cells.

J Dent Res 2008 87: 682-686. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

S. Sathishkumar, A. Meka, D. Dawson, N. House, W. Schaden, M.J. Novak, J. L. Ebersole, and L. Kesavalu
This study demonstrated the effective regeneration of bone by extracorporeal shock wave therapy and suggests that such therapy should be evaluated as an adjunct in the regeneration of periodontal tissues following periodontal disease.

J Dent Res 2008 87: 687-691. [Abstract] [Full Text] [Figures Only] [PDF]  

MMP-3 Response to Compressive Forces in vitro and in vivo

H.-H. Chang, C.-B. Wu, Y.-J. Chen, C.-Y. Weng, W.-P. Wong, Y.-J. Chen, B.-E. Chang, M.-H. Chen, and C.-C.J. Yao
This is the first registered clinical trial for collecting human bone samples involved in orthodontic tooth movement to validate laboratory findings.

J Dent Res 2008 87: 692-696. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

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