D E P A R T M E N T S:

EDITORIAL:

Editor’s Report for the Journal of Dental Research, 2007

Anthony J. (Tony) Smith
The Editor presents the state of the JDR through 2007.

J Dent Res 2008 87: 5-7. [Full Text] [Figures Only] [PDF]  

LETTERS TO THE EDITOR:

Is Artificial Fluoride Absorbed to the Same Extent as Natural Fluoride?

Trevor Sheldon, Stephen T. Holgate, I.N. Steen, A. Maguire, P.J. Moynihan, F.V. Zohoori, and J.C. Mathers
J Dent Res 2008 87: 8. [Full Text] [PDF]  

DISCOVERY!:

Sphingomyelin Degradation is a Key Factor in Dentin and Bone Mineralization: Lessons from the fro/fro Mouse

M. Goldberg, S. Opsahl, I. Aubin, D. Septier, C. Chaussain-Miller, A. Boskey, and J.-L. Guenet
The authors describe the discovery of the fro/fro mouse as the first in vivo experimental evidence that sphingomyelin and its degradation play a crucial role in bone and dentin mineralization, suggesting the need for re-classification of the non-collagenous forms of osteogenesis imperfecta and dentin dysplasia.

J Dent Res 2008 87: 9-13. [Full Text] [Figures Only] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy

S. Choi and J.N. Myers
This review focuses on the molecular mechanisms of oral carcinogenesis and the use of biologic therapy to specifically target molecules altered in oral squamous cell carcinoma.

J Dent Res 2008 87: 14-32. [Abstract] [Full Text] [Figures Only] [PDF]  

ERRATUM:

ERRATUM

J Dent Res 2008 87: 94. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

PDGF Up-regulates CSF-1 Gene Transcription in Ameloblast-like Cells

Y. Wittrant, B. Sriniketan Bhandari, H. Abboud, N. Benson, K. Woodruff, M. MacDougall, and S. Abboud-Werner
This is the first evidence that PDGF-BB is a mitogen for MEOE-3M and increases CSF-1 protein levels, predominantly by transcription. Elucidation of the cellular pathways that control CSF-1 expression may provide novel strategies for the regulation of enamel matrix formation.

J Dent Res 2008 87: 33-38. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Effects of Fluoride on the Interactions between Amelogenin and Apatite Crystals

K. Tanimoto, T. Le, L. Zhu, J. Chen, J.D.B. Featherstone, W. Li, and P. DenBesten
Fluoride incorporation into the crystal lattice alters the crystal surface to enhance amelogenin binding, with no direct interactions between fluoride and amelogenin.

J Dent Res 2008 87: 39-44. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Phenotypic Analysis of Dlx5 Overexpression in Post-natal Bone

J. Zhang, J. Zhu, P. Valverde, L. Li, S. Pageau, Q. Tu, R. Nishimura, T. Yoneda, P. Yang, W. Zheng, W. Ma, and J. Chen
Dlx5 promotes the expression of early markers of osteogenic differentiation and increases mineralization post-natally.

J Dent Res 2008 87: 45-50. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Butyric Acid Induces Apoptosis in Inflamed Fibroblasts

T. Kurita-Ochiai, S. Seto, N. Suzuki, M. Yamamoto, K. Otsuka, K. Abe, and K. Ochiai
This is the first demonstration that butyric acid can induce apoptosis in gingival fibroblasts, possibly contributing to the destruction of gingival tissues in inflamed periodontal lesions.

J Dent Res 2008 87: 51-55. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Premature Stop Codon in MMP20 Causing Amelogenesis Imperfecta

P. Papagerakis, H.-K. Lin, K.Y. Lee, Y. Hu, J.P. Simmer, J.D. Bartlett, and J.C.-C. Hu
The authors have identified an ARAI-causing point mutation in exon 1 of MMP20 in a proband with autosomal-recessive hypoplastic-hypomaturation amelogenesis imperfecta.

J Dent Res 2008 87: 56-59. [Abstract] [Full Text] [Figures Only] [PDF]  

The Effects of Social Class and Dental Attendance on Oral Health

A.N. Donaldson, B. Everitt, T. Newton, J. Steele, M. Sherriff, and E. Bower
The association between socio-economic status and the number of sound teeth in adults in the UK is partially explained by the pathway [SES barriers-to-dental-attendance dental-attendance-profile number-of-sound-teeth].

J Dent Res 2008 87: 60-64. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Anxiety and Ability to Recognize Clinical Information in Dentistry

I. Eli, D. Schwartz-Arad, and Y. Bartal
Before dental treatment (high or low on stress), patients’ ability to process information may be severely impaired.

J Dent Res 2008 87: 65-68. [Abstract] [Full Text] [Figures Only] [PDF]  

Trajectory Patterns of Dental Caries Experience in the Permanent Dentition to the Fourth Decade of Life

J.M. Broadbent, W.M. Thomson, and R. Poulton
The authors used longitudinal latent class analysis, a statistical method for identifying, summarizing, and describing the complex patterns of findings generated by life-course studies, to track caries rates across time.

J Dent Res 2008 87: 69-72. [Abstract] [Full Text] [Figures Only] [PDF]  

The Relationship between Periodontitis and Preterm Low Birthweight

M.V. Vettore, M. doC. Leal, A.T. Leão, A.M. Monteiro da Silva, G.A. Lamarca, and A. Sheiham
The authors report that chronic periodontitis is not associated with preterm low birthweight.

J Dent Res 2008 87: 73-78. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

No Alteration in Bone Mineral Density in Patients with Periodontitis

E. Hattatoglu-Sönmez, L. Özcakar, Y. Gökce-Kutsal, E. Karaagaoglu, B. Demiralp, and H. Nazliel-Erverdi
There may be a link between elevated creatinine levels and periodontitis, and persons with high BMI scores seem to be at risk for periodontitis.

J Dent Res 2008 87: 79-83. [Abstract] [Full Text] [PDF]  

Biomaterials & Bioengineering:

Refractive Index Mismatch and Monomer Reactivity Influence Composite Curing Depth

A.C. Shortall, W.M. Palin, and P. Burtscher
Optimizing filler/resin refractive index mismatch provides increased curing depth and assists shade-matching.

J Dent Res 2008 87: 84-88. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Microtensile Specimen Attachment and Shape—Finite Element Analysis

C.J. Soares, P.V. Soares, P.C.F. Santos-Filho, and S.R. Armstrong
Increasing the number of faces for specimen fixation improves the homogeneity of stress, with the best distribution occurring when all surfaces are attached.

J Dent Res 2008 87: 89-93. [Abstract] [Full Text] [Figures Only] [PDF]  

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