D E P A R T M E N T S:

DISCOVERY!:

The Effect of NIDCR R25 Grant Support on the Curriculum and Culture of a Research Non-intensive Dental School

A.M. Iacopino, M.E. Pryor, T.B. Taft, and D.P. Lynch
This is the first formal report of the effect of an R25-funded program on students, faculty, and the institution in a dental school setting.

J Dent Res 2007 86: 581-585. [Abstract] [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Interleukin 18 and Periodontal Disease

A. Orozco, E. Gemmell, M. Bickel, and G.J. Seymour
The authors review the cytokine interleukin 18 and its relevance for periodontal disease.

J Dent Res 2007 86: 586-593. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Human Hertwig’s Epithelial Root Sheath Cells Play Crucial Roles in Cementum Formation

W. Sonoyama, B.-M. Seo, T. Yamaza, and S. Shi
The authors demonstrate that human Hertwig’s epithelial root sheath (HERS) cells are capable of controlling periodontal ligament stem cell differentiation, and that HERS cells experience epithelial-mesenchymal transition to give rise to cementum-forming cells.

J Dent Res 2007 86: 594-599. [Abstract] [Full Text] [Figures Only] [PDF]  

Dioxin Alters Gene Expression in Mouse Embryonic Tooth Explants

C. Sahlberg, E. Peltonen, P.-L. Lukinmaa, and S. Alaluusua
Incomplete tooth morphogenesis caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may result from modified expression of developmentally regulated genes.

J Dent Res 2007 86: 600-605. [Abstract] [Full Text] [Figures Only] [PDF]  

The VicRK System of Streptococcus mutans Responds to Oxidative Stress

D.M. Deng, M.J. Liu, J.M. ten Cate, and W. Crielaard
The VicRK system responds to and protects against oxidative stress, and as a result, a link between oxidative/redox stess and the cariogenic nature of S. mutans can be hypothesized.

J Dent Res 2007 86: 606-610. [Abstract] [Full Text] [Figures Only] [PDF]  

Bacteria Interfere with A. actinomycetemcomitans Colonization

W. Teughels, S. Kinder Haake, I. Sliepen, M. Pauwels, J. Van Eldere, J.-J. Cassiman, and M. Quirynen
This is the first study to describe in vitro interference with epithelial colonization of an oral pathogen.

J Dent Res 2007 86: 611-617. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Detachment and Killing of Aggregatibacter actinomycetemcomitans Biofilms by Dispersin B and SDS

E.A. Izano, H. Wang, C. Ragunath, N. Ramasubbu, and J.B. Kaplan
Dispersin B, a matrix-degrading enzyme, sensitizes A. actinomycetemcomitans (A.a.) biofilms to detachment and killing by sodium dodecyl sulfate (SDS); thus, dispersin B and SDS may be useful agents for treating chronic infections caused by A.a.

J Dent Res 2007 86: 618-622. [Abstract] [Full Text] [Figures Only] [PDF]  

Intermittent Force Induces High RANKL Expression in Human Periodontal Ligament Cells

K. Nakao, T. Goto, K.K. Gunjigake, T. Konoo, S. Kobayashi, and K. Yamaguchi
IL-1ß is an autocrine factor regulating compressive force-induced RANKL expression in PDL cells, and intermittent force can effectively induce RANKL in PDL cells with less cell damage.

J Dent Res 2007 86: 623-628. [Abstract] [Full Text] [Figures Only] [PDF]  

Force-induced IL-8 from Periodontal Ligament Cells Requires IL-1ß

A. Maeda, K. Soejima, K. Bandow, K. Kuroe, K. Kakimoto, S. Miyawaki, A. Okamoto, and T. Matsuguchi
Mechano-stress-induced interleukin-8 from periodontal ligament cells may play an essential role in efficient orthodontic tooth movement.

J Dent Res 2007 86: 629-634. [Abstract] [Full Text] [Figures Only] [PDF]  

Porphyromonas gingivalis Dihydroceramides Induce Apoptosis in Endothelial Cells

J. Zahlten, B. Riep, F.C. Nichols, C. Walter, B. Schmeck, J.-P. Bernimoulin, and S. Hippenstiel
Dihydroceramides may be important virulence factors of P. gingivalis.

J Dent Res 2007 86: 635-640. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Randomized Controlled Trial of a One-minute Intervention Changing Oral Self-care Behavior

F.F. Sniehotta, V. Araújo Soares, and S.U. Dombrowski
This is the first study to provide evidence that a simple, theory-based, one-minute intervention can facilitate changes in oral self-care behavior.

J Dent Res 2007 86: 641-645. [Abstract] [Full Text] [Figures Only] [PDF]  

Time to Survival for the Restoration of the Shortened Lower Dental Arch

J.M. Thomason, P.J. Moynihan, N. Steen, and N.J.A. Jepson
In a randomized controlled trial, the authors compared the time to survival of cantilever resin-bonded fixed partial dentures and conventional removable partial dentures for restoration of shortened lower dental arches.

J Dent Res 2007 86: 646-650. [Abstract] [Full Text] [Figures Only] [PDF]  

RCT Comparing Posterior Occlusal Forms for Complete Dentures

A.F. Sutton, H.V. Worthington, and J.F. McCord
Lingualized and anatomic occlusal forms were perceived to be significantly superior in terms of chewing ability when compared with zero-degree posterior occlusal surfaces.

J Dent Res 2007 86: 651-655. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Gel Phase Formation at Resin-modified Glass-ionomer/Tooth Interfaces

E. Coutinho, Y. Yoshida, S. Inoue, R. Fukuda, J. Snauwaert, Y. Nakayama, J. De Munck, P. Lambrechts, K. Suzuki, and B. Van Meerbeek
The self-adhesiveness of resin-modified glass-ionomers (RMGIs) can be attributed to ionic bonding to hydroxyapatite around collagen, and to micro-mechanical interlocking for those RMGIs that additionally hybridize dentin.

J Dent Res 2007 86: 656-661. [Abstract] [Full Text] [Figures Only] [PDF]  

Resin Infiltration of Natural Caries Lesions

S. Paris, H. Meyer-Lueckel, and A.M. Kielbassa
Etching with 15% hydrochloric acid gel is more suitable than 37% phosphoric acid gel as a pre-treatment for caries lesions intended to be infiltrated.

J Dent Res 2007 86: 662-666. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Effect of Reinforcement on Overdenture Strain

T. Gonda, K. Ikebe, J. Dong, and T. Nokubi
This is the first study to evaluate, quantitatively, the effect of metal reinforcement on overdenture strain around copings and at the midline in vitro.

J Dent Res 2007 86: 667-671. [Abstract] [Full Text] [Figures Only] [PDF]  

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