D E P A R T M E N T S:

DISCOVERY!:

Personal Reflections on a Sensitive Subject

K. Markowitz and D.H. Pashley
The authors reflect on their involvement in the field of tooth sensitivity and how they navigated between laboratory and clinical research.

J Dent Res 2007 86: 292-295. [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Is SPARC an Evolutionarily Conserved Collagen Chaperone?

N. Martinek, J. Shahab, J. Sodek, and M. Ringuette
SPARC may play a role in regulating post-endoplasmic reticulum events that promote collagen fibrillogenesis.

J Dent Res 2007 86: 296-305. [Abstract] [Full Text] [Figures Only] [PDF]  

Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease

T.A. Silva, G.P. Garlet, S.Y. Fukada, J.S. Silva, and F.Q. Cunha
The authors summarize the findings regarding the role of chemokines in periapical and periodontal tissue inflammation, and the integration, into experimental models, of the information about the role of chemokines in human diseases.

J Dent Res 2007 86: 306-319. [Abstract] [Full Text] [Figures Only] [PDF]  

Rapid Communication:

DMP1-targeted Cre Expression in Odontoblasts and Osteocytes

Y. Lu, Y. Xie, S. Zhang, V. Dusevich, L.F. Bonewald, and J.Q. Feng
The authors describe an animal model for the preferential study of gene functions in both odontoblasts and osteocytes.

J Dent Res 2007 86: 320-325. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Validation of Amelogenesis Imperfecta Inferred from Amelogenin Evolution

S. Delgado, M. Ishiyama, and J.-Y. Sire
The authors show how evolutionary analysis, conducted within a phylogenetic framework, could help both in validating mutations in humans and in revealing amino acids which could play important roles in enamel structure and organization.

J Dent Res 2007 86: 326-330. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Transgenic Mice that Express Normal and Mutated Amelogenins

C.W. Gibson, Z.A. Yuan, Y. Li, B. Daly, C. Suggs, M.A. Aragon, F. Alawi, A.B. Kulkarni, and J.T. Wright
The authors describe a phenotype that argues for dominant-negative activity for the P70T amelogenin, and for the robust nature of the process of amelogenesis.

J Dent Res 2007 86: 331-335. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Micromolar Fluoride Alters Ameloblast Lineage Cells in vitro

Q. Yan, Y. Zhang, W. Li, and P.K. DenBesten
The authors describe multiple effects of micromolar fluoride on ameloblast-lineage cells.

J Dent Res 2007 86: 336-340. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Isolation of Human Oral Keratinocyte Progenitor/Stem Cells

K. Izumi, T. Tobita, and S.E. Feinberg
This is the first study to show Peroxisome Proliferative-activated Receptor-gamma expression in normal oral mucosa, cultured oral keratinocytes, and a human ex vivo-produced oral mucosa equivalent.

J Dent Res 2007 86: 341-346. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis

A. Beklen, M. Ainola, M. Hukkanen, C. Gürgan, T. Sorsa, and Y.T. Konttinen
Gingival fibroblasts may play an important role in tissue destruction in periodontitis via cytokine-inducible matrix metalloproteinase-1 and -3 production, in which interleukin-17 plays a role as a key regulatory cytokine.

J Dent Res 2007 86: 347-351. [Abstract] [Full Text] [Figures Only] [PDF]  

Fibrillin-2 Degradation by Matrix Metalloproteinase-2 in Periodontium

E. Tsuruga, K. Irie, and T. Yajima
The authors demonstrate, for the first time, that some active MMP-2 may degrade fibrillin-2 in periodontal ligament fibroblast cell layers, and MMP-2 may play a role in the remodeling of elastic system fibers in the periodontal ligament.

J Dent Res 2007 86: 352-356. [Abstract] [Full Text] [Figures Only] [PDF]  

Nifedipine and Cyclosporin Affect Fibroblast Calcium and Gingiva

P. Bullon, I. Gallardo, G. Goteri, C. Rubini, M. Battino, J. Ribas, and H.N. Newman
Changes in gingival collagen metabolism are not mediated by calcium intracellular oscillations.

J Dent Res 2007 86: 357-362. [Abstract] [Full Text] [Figures Only] [PDF]  

Role of NF-B in TNF--induced COX-2 Expression in Synovial Fibroblasts from Human TMJ

J. Ke, X. Long, Y. Liu, Y.F. Zhang, J. Li, W. Fang, and Q.G. Meng
Activation of NF-B is responsible for TNF--induced COX-2 expression in synovial fibroblasts from the temporomandibular joint.

J Dent Res 2007 86: 363-367. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Cortical Vascular Canals in Human Mandible and Other Bones

V.J. Kingsmill, C.M. Gray, D.R. Moles, and A. Boyde
The authors found no relationship between cortical porosity and the degree of bone mineralization.

J Dent Res 2007 86: 368-372. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Tobacco Use and Incidence of Tooth Loss among US Male Health Professionals

T. Dietrich, N.N. Maserejian, K.J. Joshipura, E.A. Krall, and R.I. Garcia
Current pipe/cigar smokers have a 20% increased risk of tooth loss compared with those who never or formerly smoked pipes/cigars.

J Dent Res 2007 86: 373-377. [Abstract] [Full Text] [PDF]  

Biomaterials & Bioengineering:

Effects of Calcium Phosphate Nanoparticles on Ca-PO₄ Composite

H.H.K. Xu, M.D. Weir, L. Sun, S. Takagi, and L.C. Chow
The authors describe new, novel nano-composites that could provide the needed combination of stress-bearing and caries-inhibiting capabilities.

J Dent Res 2007 86: 378-383. [Abstract] [Full Text] [Figures Only] [PDF]  

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