D E P A R T M E N T S:

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Genetic and Cellular Toxicology of Dental Resin Monomers

H. Schweikl, G. Spagnuolo, and G. Schmalz
The authors present recent findings regarding the induction of genotoxic stress associated with alterations in the normal cell cycle as a reaction to resin monomers, with a focus on the role of reactive oxygen species (ROS) as a source of DNA damage and cell death via apoptosis, and the influence of resin monomers on signal transduction pathways related to ROS and cell survival.

J Dent Res 2006 85: 870-877. [Abstract] [Full Text] [Figures Only] [PDF]  

The Role of Sucrose in Cariogenic Dental Biofilm Formation—New Insight

A.F. Paes Leme, H. Koo, C.M. Bellato, G. Bedi, and J.A. Cury
The authors explore the broad role of sucrose in biofilm cariogenicity, and present new insights into its influence on the pathogenesis of dental caries.

J Dent Res 2006 85: 878-887. [Abstract] [Full Text] [Figures Only] [PDF]  

ERRATUM:

ERRATUM

J Dent Res 2006 85: 960. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

The Prx1 Homeobox Gene is Critical for Molar Tooth Morphogenesis

J.M. Mitchell, D.M. Hicklin, P.M. Doughty, J.H. Hicklin, J.W. Dickert, Jr., S.M. Tolbert, R. Peterkova, and M.J. Kern
The Prx homeoproteins are critical in mesenchymal-epithelial signaling during tooth morphogenesis.

J Dent Res 2006 85: 888-893. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Origin, Splicing, and Expression of Rodent Amelogenin Exon 8

J.D. Bartlett, R. L. Ball, T. Kawai, C.E. Tye, M. Tsuchiya, and J.P. Simmer
The authors provide evidence that amelogenin exon 8 arises from a relatively recent duplication of exon 5, and that exon 8 is present only in rodent amelogenin genes.

J Dent Res 2006 85: 894-899. [Abstract] [Full Text] [Figures Only] [PDF]  

Eugenol Inhibits Sodium Currents in Dental Afferent Neurons

C.-K. Park, H.Y. Li, K.-Y. Yeon, S.J. Jung, S.-Y. Choi, S.J. Lee, S. Lee, K. Park, J.S. Kim, and S.B. Oh
The authors suggest that the inhibition of voltage-gated sodium channel currents by eugenol contributes to its analgesic effect.

J Dent Res 2006 85: 900-904. [Abstract] [Full Text] [Figures Only] [PDF]  

Fluid Shear Stress Inhibits TNF-induced Osteocyte Apoptosis

S.D. Tan, A.M. Kuijpers-Jagtman, C.M. Semeins, A.L.J.J. Bronckers, J.C. Maltha, J.W. Von den Hoff, V. Everts, and J. Klein-Nulend
The authors show, for the first time, that mechanical loading by pulsating fluid flow of physiological magnitude reduces TNF--induced apoptosis in osteocytes, but not in osteoblasts and periosteal fibroblasts.

J Dent Res 2006 85: 905-909. [Abstract] [Full Text] [Figures Only] [PDF]  

Streptococcus salivarius Promotes Mucin Putrefaction and Malodor Production by Porphyromonas gingivalis

N. Sterer and M. Rosenberg
Gram-negative and Gram-positive micro-organisms work together to degrade salivary glycoprotein and produce oral malodor.

J Dent Res 2006 85: 910-914. [Abstract] [Full Text] [Figures Only] [PDF]  

Immunogenicity and Persistence of a Targeted Anti-caries DNA Vaccine

Q.A. Xu, F. Yu, M.W. Fan, Z. Bian, Z. Chen, B. Fan, R. Jia, and J.H. Guo
Persistent immune responses are likely due to the DNA depot in the host, which acts as an immunization booster.

J Dent Res 2006 85: 915-918. [Abstract] [Full Text] [Figures Only] [PDF]  

Laser-Fluoride Effect on Root Demineralization

X.-L. Gao, J.-S. Pan, and C.-Y. Hsu
There is a significant synergistic effect of combined CO₂ laser and fluoride treatment on the inhibition of root demineralization, possibly due to laser-enhanced fluoride uptake in the root.

J Dent Res 2006 85: 919-923. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

The Effectiveness of School Dental Screening: a Cluster-randomized Control Trial

K. Milsom, A. Blinkhorn, H. Worthington, A. Threlfall, K. Buchanan, P. Kearney-Mitchell, and M. Tickle
School dental screening delivered according to 3 different models was not effective at reducing levels of active caries and increasing attendance in the population under study.

J Dent Res 2006 85: 924-928. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

ART and Conventional Root Restorations in Elders after 12 Months

E.C.M. Lo, Y. Luo, H.P. Tan, J.E. Dyson, and E.F. Corbet
In older adults, survival rates of roots restored by both atraumatic restorative treatment and the conventional technique were high and similar.

J Dent Res 2006 85: 929-932. [Abstract] [Full Text] [PDF]  

Salivary LL-37 Secretion in Individuals with Down Syndrome is Normal

G. Bachrach, G. Chaushu, M. Zigmond, E. Yefenof, A. Stabholz, J. Shapira, J. Merrick, and S. Chaushu
While the adaptive immunity of individuals with Down syndrome is impaired at the oral mucosa, the secretion rate of the LL-37 (antimicrobial peptide) component of the innate immunity is normal.

J Dent Res 2006 85: 933-936. [Abstract] [Full Text] [Figures Only] [PDF]  

Novel IRF6 Mutations in Chinese Patients with Van der Woude Syndrome

X. Du, W. Tang, W. Tian, S. Li, X. Li, L. Liu, X. Zheng, X. Chen, Y. Lin, and Y. Tang
Marked phenotypic variations in the interferon regulatory factor 6 gene (IRF6) domain may be caused by the action of certain modifier genes on IRF6 function in patients with Van der Woude syndrome.

J Dent Res 2006 85: 937-940. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Biomaterials & Bioengineering:

Chemical Interaction of Phosphoric Acid Ester with Hydroxyapatite

D. Fukegawa, S. Hayakawa, Y. Yoshida, K. Suzuki, A. Osaka, and B. Van Meerbeek
The intense chemical interaction of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) with hydroxyapatite (HAp) must be ascribed to superficial dissolution of HAp induced by the MDP adsorption and subsequent deposition of MDP-calcium salt with a solubility lower than that of CaHPO₄ · 2H₂O.

J Dent Res 2006 85: 941-944. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Residual Stress in Composites with the Thin-ring-slitting Approach

J.W. Park and J.L. Ferracane
Ring-slitting is a useful means for measuring residual stress in dental composites.

J Dent Res 2006 85: 945-949. [Abstract] [Full Text] [Figures Only] [PDF]  

Controlled Release of Chlorhexidine from UDMA-TEGDMA Resin

K.J. Anusavice, N.-Z. Zhang, and C. Shen
This is the first report of a study of chlorhexidine release from polymeric material as a function of pH and chlorhexidine content.

J Dent Res 2006 85: 950-954. [Abstract] [Full Text] [Figures Only] [PDF]  

Magnification—a New Look at a Long-known Optical Property of Dentin

A. Kienle, R. Michels, and R. Hibst
The magnification property of dentin is due to multiple scattering by the dental microstructure.

J Dent Res 2006 85: 955-959. [Abstract] [Full Text] [Figures Only] [PDF]  

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