D E P A R T M E N T S:

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

The Host Cytokine Responses and Protective Immunity in Oropharyngeal Candidiasis

A. Dongari-Bagtzoglou and P.L. Fidel, Jr.
The authors address the host cytokine responses to Candida infection as they pertain to the generation of a protective immune response in the oral mucosa.

J Dent Res 2005 84: 966-977. [Abstract] [Full Text] [Figures Only] [PDF]  

Hereditary Blood Coagulation Disorders: Management and Dental Treatment

G. Gómez-Moreno, A. Cutando-Soriano, C. Arana, and C. Scully
The authors review the evidence highlighting the areas of major concern, and suggesting management regimens, for patients with hereditary hemostatic disorders.

J Dent Res 2005 84: 978-985. [Abstract] [Full Text] [Figures Only] [PDF]  

DISCOVERY!:

Making the Cut in Dental Enamel—The Discovery of Enamelysin (MMP-20)

J.D. Bartlett
The author describes the means by which enamelysin was originally discovered.

J Dent Res 2005 84: 986-988. [Full Text] [PDF]  

RAPID COMMUNICATION:

Bioavailability of Fluoride in Drinking Water: a Human Experimental Study

A. Maguire, F.V. Zohouri, J.C. Mathers, I.N. Steen, P.N. Hindmarch, and P.J. Moynihan
This study provides the first data on F pharmacokinetics and the bioavailability of F from naturally and artificially fluoridated tap drinking-waters with different degrees of hardness.

J Dent Res 2005 84: 989-993. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

NF-B Activation in Human Dental Pulp Stem Cells by TNF and LPS

J. Chang, C. Zhang, N. Tani-Ishii, S. Shi, and C.-Y. Wang
This is the first demonstration that NF-B is functionally activated by both TNF and LPS in post-natal human dental pulp stem cells.

J Dent Res 2005 84: 994-998. [Abstract] [Full Text] [Figures Only] [PDF]  

VIP Inhibits Porphyromonas gingivalis LPS-induced Immune Responses in Human Monocytes

N. Foster, J. Cheetham, J.J. Taylor, and P.M. Preshaw
This is the first report to show the potential of vasoactive intestinal peptide as an immunomodulator of Porphyromonas gingivalis-stimulated inflammatory pathways in human monocytes.

J Dent Res 2005 84: 999-1004. [Abstract] [Full Text] [Figures Only] [PDF]  

Induction of MMP-3 by Hyaluronan Oligosaccharides in Temporomandibular Joint Chondrocytes

S. Ohno, M. Ohno-Nakahara, C.B. Knudson, and W. Knudson
Intra-articular pumping manipulation, to promote the fluid phase removal of small low-molecular-weight hyaluronan species, might reduce the pathology of TMJ arthropathy.

J Dent Res 2005 84: 1005-1009. [Abstract] [Full Text] [Figures Only] [PDF]  

Osteoclastogenic Activity during Mandibular Distraction Osteogenesis

L.C. Wang, I. Takahashi, Y. Sasano, J. Sugawara, and H. Mitani
Osteoclastogenic and osteoclastic functions are activated in distraction regenerates during the early consolidation period.

J Dent Res 2005 84: 1010-1015. [Abstract] [Full Text] [Figures Only] [PDF]  

Apigenin and tt-Farnesol with Fluoride Effects on S. mutans Biofilms and Dental Caries

H. Koo, B. Schobel, K. Scott-Anne, G. Watson, W.H. Bowen, J.A. Cury, P.L. Rosalen, and Y.K. Park
Apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride.

J Dent Res 2005 84: 1016-1020. [Abstract] [Full Text] [PDF]  

Cementum and Dentin in Hypophosphatasia

T. van den Bos, G. Handoko, A. Niehof, L.M. Ryan, S.P. Coburn, M.P. Whyte, and W. Beertsen
Mineralization of dentin is less likely under the influence of the inhibitory action of pyrophosphate than mineralization of cementum.

J Dent Res 2005 84: 1021-1025. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

X-ray Microanalysis of Elements in the Masticatory Muscle after Paresis of the Right Masseter

T. Gedrange, R. Mai, G. Richter, P. Wolf, A. Lupp, and W. Harzer
Botox^® has an indirect impact on ion concentrations, resulting in changes in muscle functional capacity and adaptive compensation of paretic muscle function by other muscles.

J Dent Res 2005 84: 1026-1030. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

MMP20 Active-site Mutation in Hypomaturation Amelogenesis Imperfecta

D. Ozdemir, P.S. Hart, O.H. Ryu, S.J. Choi, M. Ozdemir-Karatas, E. Firatli, N. Piesco, and T.C. Hart
A mutation in the MMP20 active site results in hypomaturation amelogenesis imperfecta.

J Dent Res 2005 84: 1031-1035. [Abstract] [Full Text] [Figures Only] [PDF]  

Phenotype of ENAM Mutations is Dosage-dependent

D. Ozdemir, P.S. Hart, E. Firatli, G. Aren, O.H. Ryu, and T.C. Hart
This is the second report of gene dosage affecting enamel phenotype in amelogenesis imperfecta.

J Dent Res 2005 84: 1036-1041. [Abstract] [Full Text] [Figures Only] [PDF]  

CD14 and TLR4 Gene Polymorphisms in Adult Periodontitis

M.L. Laine, S.A. Morré, L.S. Murillo, A.-J. van Winkelhoff, and A.S. Peña
This is the first report to show that a gene polymorphism of the CD14 receptor, which is involved in LPS recognition, is associated with severe periodontitis in adults.

J Dent Res 2005 84: 1042-1046. [Abstract] [Full Text] [PDF]  

Longitudinal Analysis of Heritability for Dental Caries Traits

W.A. Bretz, P.M. Corby, N.J. Schork, M.T. Robinson, M. Coelho, S. Costa, M.R. Melo Filho, R.J. Weyant, and T.C. Hart
This is the first report of heritability of dental caries net increments by surface location, consistent with a significant genetic contribution to dental caries progression and severity in both emerging and primary dentitions.

J Dent Res 2005 84: 1047-1051. [Abstract] [Full Text] [PDF]  

The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population

J. Zhou, Y. Lu, X.H. Gao, Y.C. Chen, J.J. Lu, Y.X. Bai, Y. Shen, and B.K. Wang
The growth hormone receptor gene polymorphism I526L is associated with mandibular height in the Chinese population.

J Dent Res 2005 84: 1052-1056. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Chewing Indicators between Adults with Down Syndrome and Controls

M. Hennequin, P.J. Allison, D. Faulks, T. Orliaguet, and J. Feine
This is the first study to investigate the same phenomenon (chewing frequency) in people with problematic feeding (those with Down syndrome).

J Dent Res 2005 84: 1057-1061. [Abstract] [Full Text] [Figures Only] [PDF]  

The Effect of Chewing Sugar-free Gum on Gastro-esophageal Reflux

R. Moazzez, D. Bartlett, and A. Anggiansah
Chewing sugar-free gum for half an hour after a meal can reduce acidic postprandial esophageal reflux.

J Dent Res 2005 84: 1062-1065. [Abstract] [Full Text] [PDF]  

Double-blind Study on Materials Testing with Applied Kinesiology

H.-J. Staehle, M.J. Koch, and T. Pioch
This is the first attempt to examine the reproducibility of Applied Kinesiology judgments by means of a dental materials test.

J Dent Res 2005 84: 1066-1069. [Abstract] [Full Text] [PDF]  

Biomaterials & Bioengineering:

Apatite/Amelogenin Coating on Titanium Promotes Osteogenic Gene Expression

C. Du, G.B. Schneider, R. Zaharias, C. Abbott, D. Seabold, C. Stanford, and J. Moradian-Oldak
A biomimetic coating promoting cell adhesion and osteoblast differentiation may have great potential for future dental and biomedical applications.

J Dent Res 2005 84: 1070-1074. [Abstract] [Full Text] [Figures Only] [PDF]  

Tensile Strength of Mineralized/Demineralized Human Normal and Carious Dentin

Y. Nishitani, M. Yoshiyama, F.R. Tay, B. Wadgaonkar, J. Waller, K. Agee, and D.H. Pashley
The authors measured the ultimate tensile strengths of caries-affected dentin, at various mineralized states and fully demineralized, and compared them with those of normal dentin as a function of tubule orientation.

J Dent Res 2005 84: 1075-1078. [Abstract] [Full Text] [Figures Only] [PDF]  

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