Preface

N.B. Pitts and J.W. Stamm


J Dent Res 2004 83: C4-C5. [Full Text]  

The Classic Caries Clinical Trial: Constraints and Opportunities

J.W. Stamm
The author traces the history of randomized clinical trials as they apply to the field of dental caries.

J Dent Res 2004 83: C6-C14. [Full Text] [Figures Only]  

A Report on the NIH Consensus Development Conference on Diagnosis and Management of Dental Caries Throughout Life

A.M. Horowitz
Researchers and students throughout the world must be educated to use the methods of systematic review.

J Dent Res 2004 83: C15-C17. [Full Text]  

New Developments in Medical Clinical Trials

R.B. D’Agostino, Sr. and J.M. Massaro
The authors review several new developments and long-standing good practices for conducting clinical trials.

J Dent Res 2004 83: C18-C24. [Abstract] [Full Text] [Figures Only]  

The Future of Web-based Clinical Research in Dentistry

R.G. Marks
The Internet holds promise for improving dental clinical research through its gains in efficiency, accuracy, and safety.

J Dent Res 2004 83: C25-C28. [Abstract] [Full Text] [Figures Only]  

Overview of the Impact of Changing Global Patterns of Dental Caries Experience on Caries Clinical Trials

H. Whelton
This paper describes the impact of changing global patterns of dental caries experience on caries clinical trials.

J Dent Res 2004 83: C29-C34. [Full Text] [Figures Only]  

What Constitutes Dental Caries? Histopathology of Carious Enamel and Dentin Related to the Action of Cariogenic Biofilms

E.A.M. Kidd and O. Fejerskov
The caries process is initiated by activity within the biofilm and manifested in the underlying enamel or dentin, and the caries lesion should be considered the sign or symptom of the disease.

J Dent Res 2004 83: C35-C38. [Abstract] [Full Text]  

The Continuum of Dental Caries—Evidence for a Dynamic Disease Process

J.D.B. Featherstone
Dental caries intervention methods can be tested by short-term clinical trials.

J Dent Res 2004 83: C39-C42. [Abstract] [Full Text] [Figures Only]  

Modern Concepts of Caries Measurement

N.B. Pitts
The author discusses the challenges involved in defining a range of optimal caries measurement methods that will best contribute to more efficient, modern caries clinical trials.

J Dent Res 2004 83: C43-C47. [Abstract] [Full Text] [Figures Only]  

The Challenges of Validating Diagnostic Methods and Selecting Appropriate Gold Standards

M.-C.D.N.J.M. Huysmans and C. Longbottom
The authors address some methodological issues in validating caries diagnostic methods.

J Dent Res 2004 83: C48-C52. [Abstract] [Full Text]  

The Challenges of Validating Diagnostic Methods Relative to a Conventional Two-year Caries Clinical Trial

A.R. Biesbrock, R.K. Chesters, R.P. Ellwood, and S.R. Smith
The authors address the question of appropriate validation criteria for the use of a new clinical trial methodology as a replacement for a conventional two- to three-year caries study.

J Dent Res 2004 83: C53-C55. [Abstract] [Full Text]  

Visual and Visuo-tactile Detection of Dental Caries

A.I. Ismail
The author’s review of the content validity of 29 criteria systems found substantial variability in disease processes measured, inclusion and exclusion criteria, and examination conditions.

J Dent Res 2004 83: C56-C66. [Abstract] [Full Text]  

Improving Clinical Visual Detection—Potential for Caries Clinical Trials

K.R. Ekstrand
The author discusses the use of stages of caries as outcome variables in caries clinical trials, which would have a positive influence on the trials’ duration and cost.

J Dent Res 2004 83: C67-C71. [Abstract] [Full Text]  

Bitewing and Digital Bitewing Radiography for Detection of Caries Lesions

A. Wenzel
The author describes several radiographic methods for detecting caries.

J Dent Res 2004 83: C72-C75. [Abstract] [Full Text] [Figures Only]  

Electrical Measurements for Use in Caries Clinical Trials

C. Longbottom and M.-C.D.N.J.M. Huysmans
The authors review the use of electrical measurements of caries, particularly in relation to caries clinical trials.

J Dent Res 2004 83: C76-C79. [Abstract] [Full Text]  

DIAGNOdent: An Optical Method for Caries Detection

A. Lussi, R. Hibst, and R. Paulus
The authors describe a diagnostic tool sensitive enough to detect the early onset of demineralization of dental hard tissues.

J Dent Res 2004 83: C80-C83. [Abstract] [Full Text] [Figures Only]  

Optical Methods—Quantitative Light Fluorescence

G.K. Stookey
The author reviews the available information on the use of quantitative light fluorescence for early caries detection and its potential for use in caries clinical trials.

J Dent Res 2004 83: C84-C88. [Abstract] [Full Text] [Figures Only]  

A Review of Potential New Diagnostic Modalities for Caries Lesions

A. Hall and J.M. Girkin
The authors present an overview of several potential new diagnostic methods for dental caries.

J Dent Res 2004 83: C89-C94. [Abstract] [Full Text] [Figures Only]  

Efficiency Issues Among Statistical Methods for Demonstrating Efficacy of Caries Prevention

L.A. Mancl, P.P. Hujoel, and T.A. DeRouen
The authors compare a range of analytical methods, from traditional analysis based on the number of caries onsets to newer methods that incorporate time at risk and surface-specific information.

J Dent Res 2004 83: C95-C98. [Abstract] [Full Text]  

Using Survival Methodologies in Demonstrating Caries Efficacy

A. Hannigan
The author proposes using survival time as the outcome measure that can be understood by everyone—dentists, patients, and researchers.

J Dent Res 2004 83: C99-C102. [Abstract] [Full Text] [Figures Only]  

Analysis of Clinical Trials Involving Non-cavitated Caries Lesions

P.B. Imrey and A. Kingman
CCTs require data analyses that fully exploit ordinal or continuous-scale outcome measures.

J Dent Res 2004 83: C103-C108. [Abstract] [Full Text] [Figures Only]  

Statistical Issues for Combining Multiple Caries Diagnostics for Demonstrating Caries Efficacy

B.P. Katz and E. Huntington
Ease of use, interpretability, and distributional assumptions must be considered before a consensus method for analysis of multiple diagnostic measures in caries trials can be determined.

J Dent Res 2004 83: C109-C112. [Abstract] [Full Text]  

Current Issues in Clinical Equivalence Trials

W.C. Blackwelder
The author discusses some important issues in equivalence or non-inferiority trials comparing two active treatments.

J Dent Res 2004 83: C113-C115. [Abstract] [Full Text] [Figures Only]  

The Role of Risk Factors in the Identification of Appropriate Subjects for Caries Clinical Trials: Design Considerations

M.F. Johnson
The author explores, in terms of statistical efficiency, the relative merits of identifying high-risk subjects based on specific factors, either singly or in combination.

J Dent Res 2004 83: C116-C118. [Abstract] [Full Text]  

Methods for Pooling Results from Multi-center Studies

H. Worthington
Statisticians agree that a fixed-effects model should be used.

J Dent Res 2004 83: C119-C121. [Abstract] [Full Text]  

Potential Modern Alternative Designs for Caries Clinical Trials (CCTs) and How These can be Validated against the Conventional Model

R.K. Chesters, R.P. Ellwood, A.R. Biesbrock, and S.R. Smith
Validation of new trial designs must involve comparisons with regimens previously shown in conventional CCTs to have different anticaries efficacies.

J Dent Res 2004 83: C122-C124. [Abstract] [Full Text] [Figures Only]  

International Consensus Workshop on Caries Clinical Trials (ICW-CCT)—Final Consensus Statements: Agreeing Where the Evidence Leads

N.B. Pitts and J.W. Stamm


J Dent Res 2004 83: C125-C128. [Full Text]  

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