D E P A R T M E N T S:

GUEST EDITORIAL:

The Research Challenge

Jocelyne Feine
The author, an Associate Editor of the JDR, makes a case for the JDR as the publishing vehicle for technology transfer from research to education to practice.

J Dent Res 2004 83: 589. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Dentin Regeneration by Dental Pulp Stem Cell Therapy with Recombinant Human Bone Morphogenetic Protein 2

K. Iohara, M. Nakashima, M. Ito, M. Ishikawa, A. Nakasima, and A. Akamine
The autogenous transplantation of a bone-morphogenetic-protein-2-treated pellet culture onto amputated pulp stimulated reparative dentin formation, the first step toward biological regenerative endodontic therapy.

J Dent Res 2004 83: 590-595. [Abstract] [Full Text] [Figures Only] [PDF]  

Mechanical Strain Delivers Anti-apoptotic and Proliferative Signals to Gingival Fibroblasts

T.E. Danciu, E. Gagari, R.M. Adam, P.D. Damoulis, and M.R. Freeman
This is the first report of FoxO1 and FoxO4 activation in gingival fibroblasts in response to a mechanical stimulus.

J Dent Res 2004 83: 596-601. [Abstract] [Full Text] [Figures Only] [PDF]  

Cementoblast Gene Expression is Regulated by Porphyromonas gingivalis Lipopolysaccharide Partially via Toll-like Receptor-4/MD-2

F.H. Nociti, Jr., B.L. Foster, S.P. Barros, R.P. Darveau, and M.J. Somerman
Exposure of cementoblasts to Porphyromonas gingivalis lipopolysaccharide treatment can alter cell function by regulating markers of osteoclastic activity, thereby potentially affecting the inflammation-associated resorption of mineralized tissues.

J Dent Res 2004 83: 602-607. [Abstract] [Full Text] [Figures Only] [PDF]  

Amelogenesis Imperfecta in a New Animal Model—a Mutation in Chromosome 5 (human 4q21)

H. Seedorf, I.N. Springer, E. Grundner-Culemann, H.-K. Albers, A. Reis, H. Fuchs, M. Hrabe de Angelis, and Y. Açil
The authors introduce a new mutant for autosomal-dominant amelogenesis imperfecta.

J Dent Res 2004 83: 608-612. [Abstract] [Full Text] [Figures Only] [PDF]  

Induction of Calcification in MC3T3-E1 Cells by Inorganic Polyphosphate

Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh, and T. Kohgo
Poly(P)-dependent induction of polyphosphatase activities may promote calcification in MC3T3-E1 cells.

J Dent Res 2004 83: 613-618. [Abstract] [Full Text] [Figures Only] [PDF]  

Oxidative Stress-induced DNA Damage in the Synovial Cells of the Temporomandibular Joint in the Rat

T. Yamaza, K.F. Masuda, I. Atsuta, K. Nishijima, M.A. Kido, and T. Tanaka
Condylar hypermovement induces the proliferation of synovial cells, and oxidative stress leads to the progression of synovial hyperplasia via DNA damage of the synovial cells in TMJs after mechanical loading.

J Dent Res 2004 83: 619-624. [Abstract] [Full Text] [Figures Only] [PDF]  

Denervation Resulting in Dento-Alveolar Ankylosis Associated with Decreased Malassez Epithelium

K. Fujiyama, T. Yamashiro, T. Fukunaga, T.A. Balam, L. Zheng, and T. Takano-Yamamoto
The authors suggest that Malassez epithelium may negatively regulate root resorption and induce acellular cementum formation.

J Dent Res 2004 83: 625-629. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

An Eight-year Follow-up to a Randomized Clinical Trial of Participant Satisfaction with Three Types of Mandibular Implant-retained Overdentures

R. Timmerman, G.T. Stoker, D. Wismeijer, P. Oosterveld, J.I.J.F. Vermeeren, and M.A.J. van Waas
A mandibular overdenture retained by 2 implants with a single bar may be the best treatment strategy for edentulous people with atrophic ridges.

J Dent Res 2004 83: 630-633. [Abstract] [Full Text] [PDF]  

Estimating Rates of New Root Caries in Older Adults

S.O. Griffin, P.M. Griffin, J.L. Swann, and N. Zlobin
Older adults experience high rates of new caries and could benefit from caries-prevention programs.

J Dent Res 2004 83: 634-638. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Prevalence of Human Herpesvirus-8 Salivary Shedding in HIV Increases with CD4 Count

M. Gandhi, D.M. Koelle, N. Ameli, P. Bacchetti, J.S. Greenspan, M. Navazesh, K. Anastos, and R.M. Greenblatt
The authors suggest an increased potential for HHV-8 transmission early in HIV infection, with implications for HHV-8 prevention.

J Dent Res 2004 83: 639-643. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Water-dependent Interfacial Transition Zone in Resin-modified Glass-ionomer Cement/Dentin Interfaces

F.R. Tay, S.K. Sidhu, T.F. Watson, and D.H. Pashley
The absorption layer is formed only in the presence of water derived from hydrated dentin and is crucial for mediating the bond between resin-modified glass-ionomer cements and dentin.

J Dent Res 2004 83: 644-649. [Abstract] [Full Text] [Figures Only] [PDF]  

Laboratory Stresses and Tractional Forces on the TMJ Disc Surface

J.C. Nickel, L.R. Iwasaki, M.W. Beatty, and D.B. Marx
The authors’ findings are consistent with current mechanical theories of the time-dependent effects of compressive loading of cartilage.

J Dent Res 2004 83: 650-654. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

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