D E P A R T M E N T S:

SPEECH:

Seven Secrets to Discovery

Kenneth J. Anusavice
This is the text of the address delivered by the AADR President-elect at the Opening Ceremonies of the 32nd Annual Meeting of the American Association for Dental Research, March 12, 2003, in San Antonio, TX.

J Dent Res 2003 82: 413-414. [Full Text] [PDF]  

GUEST EDITORIAL:

International Standards for Clinical Trial Conduct and Reporting

Richard Niederman, Derek Richards, Debora Matthews, Daniel Shugars, Helen Worthington, and William Shaw
The authors make a plea for international standardization in the conduct and reporting of clinical trials.

J Dent Res 2003 82: 415-416. [Full Text] [PDF]  

DISCOVERY!:

Neuroendocrine-Immune Surveillance of Osteosarcoma: Emerging Hypothesis

P. Prolo, F. Chiappelli, G. Bernard, M. Fiala, A. Ibarra, M.L. Sartori, A. Dovio, and A. Angeli
The authors discuss the mechanisms by which apoptosis of osteosarcoma cells is modulated by the neuroendocrine-immune system, and potential physiological implications.

J Dent Res 2003 82: 417-421. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Clinical:

Class II Antigen-presenting Dendritic Cell and Nerve Fiber Responses to Cavities, Caries, or Caries Treatment in Human Teeth

K. Yoshiba, N. Yoshiba, and M. Iwaku
Dental pulps respond differently to cavity preparations and restorations between normal and caries conditions, and immunoresponses persist for many months, even after caries treatment.

J Dent Res 2003 82: 422-427. [Abstract] [Full Text] [Figures Only] [PDF]  

Transforming Growth Factor-ß and Interleukin 10 in Oral Implant Sites in Humans

G. Schierano, G. Bellone, E. Cassarino, M. Pagano, G. Preti, and G. Emanuelli
Newly classified TGF-ß and/or IL-10 secreting T regulatory/T helper 3 cells may populate implant insertion sites.

J Dent Res 2003 82: 428-432. [Abstract] [Full Text] [Figures Only] [PDF]  

Heterozygous Mutation in the SAM Domain of p63 Underlies Rapp-Hodgkin Ectodermal Dysplasia

P.N. Kantaputra, T. Hamada, T. Kumchai, and J.A. McGrath
In addition to describing the first genetic abnormality in Rapp-Hodgkin Syndrome, this research discloses the molecular basis of RHS, providing new clinico-pathological insight into the consequences of a specific p63 SAM domain mutation in epithelial development.

J Dent Res 2003 82: 433-437. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Accuracy of a System for Creating 3D Computer Models of Dental Arches

R. DeLong, M. Heinzen, J.S. Hodges, C.-C. Ko, and W.H. Douglas
The authors measured the accuracy and precision of a system for creating three-dimensional images of dental arches and concluded that it produced computer models with sufficient accuracy for clinical application.

J Dent Res 2003 82: 438-442. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Interaction of Dendrimers (Artificial Proteins) with Biological Hydroxyapatite Crystals

H. Chen, M. Banaszak Holl, B.G. Orr, I. Majoros, and B.H. Clarkson
The authors show the potential of artificial proteins, dendrimers, to be used as nanoprobes to mimic the pattern and determine the strength of binding of proteins to crystal surfaces.

J Dent Res 2003 82: 443-448. [Abstract] [Full Text] [Figures Only] [PDF]  

Osteoblast Precursor Cell Attachment on Heat-treated Calcium Phosphate Coatings

Y. Yang, J.D. Bumgardner, R. Cavin, D.L. Carnes, and J.L Ong
Heat treatment of calcium phosphate coatings affects cell attachment.

J Dent Res 2003 82: 449-453. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

IGF-1 Signaling Enhances Cell Survival in Periodontal Ligament Fibroblasts vs. Gingival Fibroblasts

X. Han and S. Amar
The authors suggest that the reduced apoptotic rate in periodontal ligament fibroblasts compared with gingival fibroblasts results in part from the up-regulation of the IGF-1 signaling pathway.

J Dent Res 2003 82: 454-459. [Abstract] [Full Text] [Figures Only] [PDF]  

Dentin-induced in vivo Inflammatory Response and in vitro Activation of Murine Macrophages

V.S. Lara, F. Figueiredo, T.A. da Silva, and F.Q. Cunha
This work demonstrates for the first time the ability of dentin to elicit inflammatory events.

J Dent Res 2003 82: 460-465. [Abstract] [Full Text] [Figures Only] [PDF]  

Lipoteichoic Acid Up-regulates VEGF Expression in Macrophages and Pulp Cells

P.D.S. Telles, C.T. Hanks, M.A.A.M. Machado, and J.E. Nör
This work constitutes the first demonstration that lipoteichoic acid is sufficient to induce expression of a pro-angiogenic factor.

J Dent Res 2003 82: 466-470. [Abstract] [Full Text] [Figures Only] [PDF]  

MG2 and Lactoferrin Form a Heterotypic Complex in Salivary Secretions

R.V. Soares, C.C. Siqueira, L.S. Bruno, F.G. Oppenheim, G.D. Offner, and R.F. Troxler
The authors describe a heterotypic complex that may enhance the properties of certain salivary components in the oral environment.

J Dent Res 2003 82: 471-475. [Abstract] [Full Text] [Figures Only] [PDF]  

Age-related Decreases in the Response of Aquaporin-5 to Acetylcholine in Rat Parotid Glands

N. Inoue, H. Iida, Z. Yuan, Y. Ishikawa, and H. Ishida
The quinuclidine derivative SNI-2011 might have therapeutic benefit for the treatment of age-related xerostomia.

J Dent Res 2003 82: 476-480. [Abstract] [Full Text] [Figures Only] [PDF]  

Myosin Heavy-chain Isoform Composition of Human Single Jaw-muscle Fibers

J.A.M. Korfage and T.M.G.J. Van Eijden
This is the first study that used single fibers of human jaw muscles to determine the myosin heavy-chain isoform composition of fibers co-expressing more than one isoform.

J Dent Res 2003 82: 481-485. [Abstract] [Full Text] [Figures Only] [PDF]  

Root Resorption Related to Hypofunctional Periodontium in Experimental Tooth Movement

S. Sringkarnboriboon, Y. Matsumoto, and K. Soma
Orthodontic movement of non-occluding teeth should be performed with caution.

J Dent Res 2003 82: 486-490. [Abstract] [Full Text] [Figures Only] [PDF]  

Food Texture Differences affect Energy Metabolism in Rats

K. Oka, A. Sakuarae, T. Fujise, H. Yoshimatsu, T. Sakata, and M. Nakata
Food texture affects energy metabolism by changing post-prandial thermogenesis, a long-term deficiency in which, associated with soft foods, results in a greater tendency to obesity.

J Dent Res 2003 82: 491-494. [Abstract] [Full Text] [Figures Only] [PDF]  

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