D E P A R T M E N T S:

DISCOVERY!:

Biomineralization: On the Trail of the Phosphate. Part I: Chance Encounters and the Path to Dentin

Arthur Veis
In the first of a two-part series, the author traces his 30-year path from physical to protein chemistry.

J Dent Res 2003 82: 941-943. [Full Text] [Figures Only] [PDF]  

CONCISE REVIEWS:

Four Reasons to Consider a Novel Class of Innate Immune Molecules in the Oral Epithelium

E.E. LeClair
The author introduces a recently recognized class of mammalian proteins, with similarity to palate, lung, and nasal epithelium clone, that act as sensors of Gram-negative bacteria in the oral cavity.

J Dent Res 2003 82: 944-950. [Abstract] [Full Text] [Figures Only] [PDF]  

RAPID COMMUNICATION:

Tissue-engineered Neogenesis of Human-shaped Mandibular Condyle from Rat Mesenchymal Stem Cells

A. Alhadlaq and J.J. Mao
The authors present evidence supporting the therapeutic use of tissue-engineered mandibular condyles in patients suffering from osteoarthritis, rheumatoid arthritis, injuries, and congenital anomalies.

J Dent Res 2003 82: 951-956. [Abstract] [Full Text] [Figures Only] [PDF]  

The Importance of Intrafibrillar Mineralization of Collagen on the Mechanical Properties of Dentin

J.H. Kinney, S. Habelitz, S.J. Marshall, and G.W. Marshall
When intrafibrillar mineralization is absent, the expected linear relationship between mineral concentration and Young's modulus or hardness vanishes.

J Dent Res 2003 82: 957-961. [Abstract] [Full Text] [Figures Only] [PDF]  

BOOK REVIEW:

DENTAL BIOMECHANICS: Arturo N. Natali, Editor, ISBN 0-415-30666-3 £65.00, Taylor and Francis, Taylor and Francis Group, London, UK and New York, USA

Angelo Caputo
J Dent Res 2003 82: 1023. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biomaterials & Bioengineering:

Effects of Static Magnetic Fields on Bone Formation in Rat Osteoblast Cultures

Y. Yamamoto, Y. Ohsaki, T. Goto, A. Nakasima, and T. Iijima
Static magnetic fields stimulate bone formation by promoting osteoblastic differentiation and/or activation.

J Dent Res 2003 82: 962-966. [Abstract] [Full Text] [Figures Only] [PDF]  

Does Layering Minimize Shrinkage Stresses in Composite Restorations?

R.H. Kuijs, W.M.M. Fennis, C.M. Kreulen, M. Barink, and N. Verdonschot
For a cusp-replacing restoration, the order in which the composite layers are placed has almost no influence on the developed stresses.

J Dent Res 2003 82: 967-971. [Abstract] [Full Text] [Figures Only] [PDF]  

Effect of Surface Roughness on Flexural Strength of Veneer Ceramics

H. Fischer, M. Schäfer, and R. Marx
Final preparation of a ceramic restoration has a decisive influence on the strength of the material, and ceramic veneering materials can be compared more objectively with respect to strength by means of roughness-free strength values.

J Dent Res 2003 82: 972-975. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

Comparison of Stem-cell-mediated Osteogenesis and Dentinogenesis

S. Batouli, M. Miura, J. Brahim, T.W. Tsutsui, L.W. Fisher, S. Gronthos, P. Gehron Robey, and S. Shi
Osteogenesis and dentinogenesis mediated by bone marrow stromal stem cells and dental pulp stem cells, respectively, may be regulated by distinct mechanisms, leading to the different organization of the mineralized and non-mineralized tissues.

J Dent Res 2003 82: 976-981. [Abstract] [Full Text] [Figures Only] [PDF]  

Relative Levels of mRNA Encoding Enamel Proteins in Enamel Organ Epithelia and Odontoblasts

T. Nagano, S. Oida, H. Ando, K. Gomi, T. Arai, and M. Fukae
Odontoblasts are involved in the formation of the enamel layer adjacent to the enamel-dentin junction.

J Dent Res 2003 82: 982-986. [Abstract] [Full Text] [Figures Only] [PDF]  

Role of the Activation of the Nuclear Enzyme Poly(ADP-Ribose) Polymerase in the Pathogenesis of Periodontitis

Z. Lohinai, J.G. Mabley, E. Fehér, A. Marton, K. Komjáti, and C. Szabó
Inhibition of nuclear poly(ADP-ribose) polymerase enzyme may represent a novel host response modulatory approach for the therapy of periodontitis.

J Dent Res 2003 82: 987-992. [Abstract] [Full Text] [Figures Only] [PDF]  

Central Muscarinic Receptors Signal Pilocarpine-induced Salivation

A.C.T. Takakura, T. S. Moreira, S.C. Laitano, L.A. De Luca, Jr., A. Renzi, and J. V. Menani
The authors provide unequivocal evidence for a centrally dependent mechanism of salivation induced by systemic pilocarpine.

J Dent Res 2003 82: 993-997. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Relationship of Periodontal Disease and Edentulism to Stroke/TIA

J.R. Elter, S. Offenbacher, J.F. Toole, and J.D. Beck
This study shows a weak independent association of attachment level with stroke/TIA.

J Dent Res 2003 82: 998-1001. [Abstract] [Full Text] [PDF] [Appendix]  

The Human KROX-26/ZNF22 Gene is Expressed at Sites of Tooth Formation and Maps to the Locus for Permanent Tooth Agenesis (He-Zhao Deficiency)

Y. Gao, H. Kobayashi, and B. Ganss
The authors demonstrate a potential function for KROX-26 in the molecular regulation of tooth formation in humans.

J Dent Res 2003 82: 1002-1007. [Abstract] [Full Text] [Figures Only] [PDF]  

Novel Identification of a Four-base-pair Deletion Mutation in PITX2 in a Rieger Syndrome Family

Y. Wang, H. Zhao, X. Zhang, and H. Feng
The authors report a novel 4-bp deletion mutation in PITX2 that is responsible for Rieger syndrome in a three-generation Chinese family; this is the first unquestionable loss-of-function mutation, deleting all functionally important parts of the protein.

J Dent Res 2003 82: 1008-1012. [Abstract] [Full Text] [Figures Only] [PDF]  

MSX1 Gene is Deleted in Wolf-Hirschhorn Syndrome Patients with Oligodontia

P. Nieminen, J. Kotilainen, Y. Aalto, S. Knuutila, S. Pirinen, and I. Thesleff
Haploinsufficiency for the MSX1 gene serves as a mechanism that causes selective tooth agenesis but, alone, is not enough to cause oral clefts.

J Dent Res 2003 82: 1013-1017. [Abstract] [Full Text] [Figures Only] [PDF]  

The in vivo Levels of Matrix Metalloproteinase-1 and -8 in Gingival Crevicular Fluid during Initial Orthodontic Tooth Movement

S. Apajalahti, T. Sorsa, S. Railavo, and T. Ingman
This is the first report of the in vivo levels, molecular forms, and degree of activation of MMP-1 and -8 in humans.

J Dent Res 2003 82: 1018-1022. [Abstract] [Full Text] [Figures Only] [PDF]  

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