D E P A R T M E N T S:

DISCOVERY!:

Pain in the Trigeminal System: from Orofacial Nociception to Neural Network Modeling

A. Woda
The author describes the evolution of interdisciplinary knowledge transmission from a science to a dental faculty through a human chain.

J Dent Res 2003 82: 764-768. [Full Text] [Figures Only] [PDF]  

CONCISE REVIEWS:

Prions and the Oral Cavity

A.J. Smith, J. Bagg, J.W. Ironside, R.G. Will, and C. Scully
This article reviews the existing knowledge base on the nature of prions, their distribution in oral tissues, and the implications for dental treatment.

J Dent Res 2003 82: 769-775. [Abstract] [Full Text] [PDF]  

RAPID COMMUNICATION:

The Dentin Matrix Protein 1 (Dmp1) is Specifically Expressed in Mineralized, but not Soft, Tissues during Development

J.Q. Feng, H. Huang, Y. Lu, L. Ye, Y. Xie, T.W. Tsutsui, T. Kunieda, T. Castranio, G. Scott, L.B. Bonewald, and Y. Mishina
The authors describe for the first time the expression of Dmp1 in pulp cells, the precursors of odontoblasts, and suggest that Dmp1 is not essential for early mouse skeletal or dental development.

J Dent Res 2003 82: 776-780. [Abstract] [Full Text] [Figures Only] [PDF]  

IN MEMORIAM:

Professor Graham Embery IADR President, 2001-2002

Stephen Challacombe and Rachel Waddington
J Dent Res 2003 82: 856. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Activation of Vanilloid Receptor 1 (VR1) by Eugenol

B.H. Yang, Z.G. Piao, Y.-B. Kim, C.-H. Lee, J.K. Lee, K. Park, J.S. Kim, and S.B. Oh
The authors provide strong evidence that eugenol produces its effects, at least in part, via VR1 expressed by the sensory nerve endings in the teeth.

J Dent Res 2003 82: 781-785. [Abstract] [Full Text] [Figures Only] [PDF]  

Genetic Mapping of the Absence of Third Molars in EL Mice to Chromosome 3

R. Nomura, T. Shimizu, Y. Asada, S. Hirukawa, and T. Maeda
The candidate locus for the absence of M3 in EL mice has been mapped on the middle of chromosome 3.

J Dent Res 2003 82: 786-790. [Abstract] [Full Text] [Figures Only] [PDF]  

Parathyroid Hormone Protects against Periodontitis-associated Bone Loss

S.P. Barros, M.A.D. Silva, M.J. Somerman, and F.H. Nociti, Jr.
Intermittent PTH administration is able to protect against periodontitis-associated bone loss in a rodent model.

J Dent Res 2003 82: 791-795. [Abstract] [Full Text] [Figures Only] [PDF]  

Proteolysis of ICAM-1 on Human Oral Epithelial Cells by Gingipains

H. Tada, S. Sugawara, E. Nemoto, T. Imamura, J. Potempa, J. Travis, H. Shimauchi, and H. Takada
Gingipains cleave ICAM-1 on oral epithelial cells, consequently disrupting PMN-oral epithelial cell interaction, and are involved in immune evasion by the bacterium in periodontal tissues.

J Dent Res 2003 82: 796-801. [Abstract] [Full Text] [Figures Only] [PDF]  

Apoptosis in Human Oral Squamous Cell Carcinomas is Induced by 15-Deoxy-^12,14-Prostaglandin J₂ but not by Troglitazone

K. Fukuchi, M. Date, Y. Azuma, M. Shinohara, H. Takahashi, and K. Ohura
This is the first report of apoptosis induced by 15-d-PGJ2 in human oral SCC cell lines.

J Dent Res 2003 82: 802-806. [Abstract] [Full Text] [Figures Only] [PDF]  

A Determination of Tumor Necrosis Factor Expression in TMJ Inflammation with the Use of Microarray Analysis

R. Spears, R. Oakes, C. Moore, L.L. Bellinger, and B. Hutchins
This is the first report of gene microarray analysis used for the examination of changes that occur in TMJ tissues after the initiation of an inflammatory response.

J Dent Res 2003 82: 807-813. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

TEGDMA Causes Apoptosis in Primary Human Gingival Fibroblasts

V. Janke, N. von Neuhoff, B. Schlegelberger, G. Leyhausen, and W. Geurtsen
The authors provide the first evidence that severe chemical-biological interactions caused by elevated concentrations of TEGDMA in vitro are predominantly due to apoptosis rather than to necrosis.

J Dent Res 2003 82: 814-818. [Abstract] [Full Text] [Figures Only] [PDF]  

Prediction of Mechanical Properties of the Cancellous Bone of the Mandibular Condyle

L.J. van Ruijven, E.B.W. Giesen, M. Farella, and T.M.G.J. van Eijden
This is the first report on the actual tissue stiffness of the cancellous bone of the mandibular condyle.

J Dent Res 2003 82: 819-823. [Abstract] [Full Text] [Figures Only] [PDF]  

Effect of TEGDMA/BisGMA Ratio on Stress Development and Viscoelastic Properties of Experimental Two-paste Composites

A.J. Feilzer and B.S. Dauvillier
The authors investigated the hypothesis that an increase of the TEGDMA/BisGMA ratio in a resin composite will lead to a more favorable viscous flow property.

J Dent Res 2003 82: 824-828. [Abstract] [Full Text] [Figures Only] [PDF]  

Fluoride Release from a Resin-modified Glass-ionomer Cement in a Continuous-flow System: Effect of pH

C.M. Carey, M. Spencer, R.J. Gove, and F.C. Eichmiller
The release of fluoride from dental restorative materials must be evaluated under conditions that model the environment of the mouth if any beneficial effects or limitations of the released fluoride are to be fully appreciated.

J Dent Res 2003 82: 829-832. [Abstract] [Full Text] [Figures Only] [PDF]  

Influence of Post-deposition Heating Time and the Presence of Water Vapor on Sputter-coated Calcium Phosphate Crystallinity

Y. Yang, K.-H. Kim, C.M. Agrawal, and J.L. Ong
The presence of water vapor and post-deposition heat treatment time significantly affect the crystallinity of CaP coatings, which may ultimately affect bone healing.

J Dent Res 2003 82: 833-837. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Detection of Vascular Disease Risk in Women by Panoramic Radiography

A. Taguchi, Y. Suei, M. Sanada, Y. Higashi, M. Ohtsuka, T. Nakamoto, M. Tsuda, K. Ohama, and K. Tanimoto
Panoramic radiographic measurements may be associated with increased vascular disease risk in post-menopausal women.

J Dent Res 2003 82: 838-843. [Abstract] [Full Text] [Figures Only] [PDF]  

Aging and Secretory Reserve Capacity of Major Salivary Glands

E.M. Ghezzi and J.A. Ship
Salivary gland output is more adversely affected by an anti-sialogogue in healthy older vs. younger adults, supporting the secretory reserve hypothesis of salivary function.

J Dent Res 2003 82: 844-848. [Abstract] [Full Text] [Figures Only] [PDF]  

Detectable Dioxins in Human Saliva and Their Effects on Gingival Epithelial Cells

T. Ogawa, Y. Asai, M. Yamashita, and T. Takasuga
This is the first known attempt to detect dioxins in saliva, and PCBs and PCDDs were found in both saliva and blood specimens, constituting a possible risk factor for periodontal diseases.

J Dent Res 2003 82: 849-853. [Abstract] [Full Text] [Figures Only] [PDF]  

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