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Figure 2. Eugenol inhibited voltage-gated K+ currents in both capsaicin-sensitive and capsaicin-insensitive rat trigeminal ganglion neurons. (A) Representative current traces of voltage-gated K+ currents under control, eugenol (1 mM), and capsaicin (1 µM), respectively, in 2 trigeminal ganglion neurons. Eugenol (1 mM) inhibited voltage-gated K+ currents in both capsaicin-sensitive (left) and capsaicin-insensitive (right) trigeminal ganglion neurons. (B) Representative time-courses of the inhibition of voltage-gated K+ currents by eugenol in capsaicin-sensitive (black circle) and capsaicin-insensitive (white circle) trigeminal ganglion neurons (left). The summary of the inhibition of voltage-gated K+ currents in trigeminal ganglion neurons (right) indicated that eugenol (1 mM)-induced inhibition in capsaicin-insensitive neurons was similar to that obtained in capsaicin-sensitive neurons (mean ± SEM, p > 0.05). The number in parentheses represents the number of cells studied.
