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Figure 3. VIP inhibited Pg LPS-stimulated IL-18 and IL-18BPa production by THP1 monocytes. (A) VIP (10–8 M) inhibited Pg LPS (100 ng/mL)-stimulated IL-18 production in THP1 monocytes cultured for 6-48 hrs. (B) VIP (10–8 M) inhibited Pg LPS (100 ng/mL)-stimulated IL-18BPa production in THP1 monocytes cultured for 6-48 hrs. IL-18 and IL-18BPa levels were measured by ELISA. Each value is a mean (± SD) of 3 experiments recorded on 3 separate occasions. *p < 0.05 compared with cells stimulated with LPS in the absence of VIP.
