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Figure 2. Interaction of IL-18BPa with IL-18 in THP1 culture supernatants. Co-culture of anti-IL-18BPa antibodies with THP1 monocytes in the presence of Pg LPS (100 ng/mL) for 24 hrs significantly increased the concentration of free IL-18 measured in cell supernatants, compared with antibody-free controls. IL-18BPa levels were measured by ELISA. Each value is a mean (± SD) of 3 experiments recorded on 3 separate occasions. *p < 0.05 compared with controls.

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