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Figure 2. A. actinomycetemcomitans LPS induces significant linear bone loss, which is blocked by an orally active p38 inhibitor. (A) Reformatted µCT isoform display from 8-week-old A. actinomycetemcomitans LPS-injected rat maxillae exhibits dramatic palatal and interproximal bone loss. Landmarks used for linear measurements were the cemento-enamel junction (CEJ) to the alveolar bone crest (ABC). (B) Linear bone loss as measured from the CEJ to the ABC (mean ± SEM). Significant bone loss (p < 0.01) was observed between control (n = 6) and A. actinomycetemcomitans LPS-injected rats (n = 12). Significant reduction of LPS-induced periodontal bone loss (**p < 0.01 for SD-282 [15 mg/kg; n = 8] and *p < 0.05 for SD-282 [45 mg/kg; n = 8]). Used with permission (Kirkwood et al., 2007).
