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Figure 1. Time-course of naproxen accumulation by cultured SCC-25 monolayers. Cells were incubated for 10 min at 37°C in HBSS prior to the addition of 50 µg/mL naproxen. At the indicated times, the naproxen solution was removed, and extracellular naproxen was rapidly washed away. The data represent the mean of 6 experiments. Inset: Representative Lineweaver-Burk plot of naproxen transport by SCC-25 cells observed in a representative experiment conducted over a three-minute interval at 37°C.
