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Figure 4. Representative 12-hour light period hypnogram on the first day for a SHAM (A), Freund’s adjuvant (FA) (B), SHAM/COX2i (C), and FA/COX2i (D) rats. Values were recorded at 30-second intervals in each stage. ’W’ represents a period of wakefulness; nREM, non-REM sleep; and REM, REM sleep. Note the marked fragmentation and reduced long sleep period in orofacial pain, and marked alterations after the treatment with etoricoxib.

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