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Figure 1. (A) Effect of cyclo-oxygenase-2 inhibitor on sleep efficiency in the acute inflammatory model induced by Freund’s adjuvant application to the TMJ on 2 light periods of recording. Each set of columns represents an experimental group. (B) Effect of cyclo-oxygenase-2 inhibitor on sleep parameters in the acute inflammatory model induced by Freund’s adjuvant application in the TMJ on 2 light periods of recording. SHAM group: injected with saline. FA group: injected with Freund’s adjuvant. Saline (SHAM/COX2i) and Freund’s adjuvant (FA/COX2i) injected into the TMJ treated with etoricoxib (COX-2i, 90 mg/kg, p.o.). W1, wake day 1; W2, wake day 2; nREM1, non-REM sleep day 1; nREM2, non-REM sleep day 2; REM1, rapid eye movement sleep day 1; REM2, rapid eye movement sleep day 2. The values are expressed as mean ± SD. *Differ from SHAM group (p < 0.05). #Differ from Freund’s adjuvant group (p < 0.01). ¥Differ from SHAM/COX2i group (p < 0.05). 
Differ from first day of SHAM/COX2i group (p < 0.01). N = 8/group.
