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Figure 1. Kinetics of fibroblast-induced gel contraction. (a) Collagen gel contraction by paired oral and skin fibroblasts under control conditions. Oral fibroblasts induced significantly increased contraction compared with skin cells at all concentrations studied (p < 0.05). (b,c) Effect of total MMP (GM1489) and MMP-3 inhibition on collagen gel contraction kinetics by (b) oral and (c) skin fibroblasts over a seven-day study period. Both inhibitors significantly reduced gel contraction by oral fibroblasts at all time-points (p < 0.05); GM1489 significantly inhibited gel contraction by skin fibroblasts at all time-points (p < 0.05). Studies were carried out in triplicate on 3 paired skin and oral fibroblast populations. Data are expressed as mean ± SE.
