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Figure 3. Immunolocalization of pro- and active MMP-1 (A,C) and MMP-3 (B,D) in gingival tissue. The numbers of MMP-1- and MMP-3-immunoreactive cells were increased in persons with periodontitis. The number of MMP-1-immunoreactive cells was 1426 ± 96 vs. 497 ± 36 (***p < 0.001) and MMP-3-immunoreactive cells 1103 ± 95 vs. 274 ± 14 (***p < 0.001) cells/mm2 in persons with periodontitis compared with healthy controls, respectively. Scale bar = 100 µm. The histograms demonstrate the numbers of MMP-1- and MMP-3-positive cells in control individuals and persons with periodontitis.
