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Figure 2. Amino-acid sequence of human amelogenin with indication of important residues inferred from the alignment of 52 mammalian sequences (A) and of 80 amniote sequences (52 mammals, 6 crocodiles, and 22 squamates) (B). (The alignments are presented in APPENDIX 2.) Exon 4 (14 residues) was not included, because it was absent in most species studied. Signal peptide is on the grey background. The protein sequence (191 amino acids) is numbered from methionine (1). Large characters = residues unchanged; italics = residues that can be substituted for by an amino acid from the same group only. Small characters = residues for which substitution can be made. Boldface characters = the 5 residues known to lead to amelogenesis imperfecta after substitution.
