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Figure 1. Tissue factor induction by oral streptococci in a transwell system. PBMC (106) were stimulated with 4 strains of oral streptococci (107) in 200 µL enriched RPMI without antibiotics in transwell inserts. The up-regulation of endothelial TF activity in 6 hrs was measured with the factor Xa assay (mU/mL). Data from 4 independent experiments were analyzed with ANOVA. *Significant increase of TF activity when compared with PBMC control by Tukey’s HSD (p < 0.005). The vertical bars represent standard errors.
