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Figure 4. Comparisons of quantities of Phex and Npt2b mRNA in cultured tooth germs. (a) Relative quantities of Phex mRNA (mean ± SEM) in tooth germs cultured with or without oligo-deoxynucleotide (n= 8 of each). The expression level in tooth germs cultured with antisense oligo-deoxynucleotide was significantly lower than that of tooth germs cultured with sense oligo-deoxynucleotide and without any oligo-deoxynucleotides (*P < 0.01, Mann-Whitney U-test). (b) Relative quantities of Npt2b mRNA (mean ± SEM) in tooth germs cultured with or without oligo-deoxynucleotide (n = 8 of each). The expression level in tooth germs cultured with antisense ODN was significantly lower than that in tooth germs cultured with sense oligo-deoxynucleotide and without oligo-deoxynucleotide (*P < 0.01, Mann-Whitney U-test).
