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Figure 2. Periapical bone resorption caused by endodontic infection. (A) Micro CT image showing the pivot section of a mandibular first left molar and the area of resorption (outlined in white). (B) Comparison of areas (expressed in mm2) of periapical bone resorption in the different experimental groups. SCID animals infected with T. denticola showed periapical lesions of greater size compared with those in SCID and WT animals infected with red complex (p < 0.05). Sham controls presented significantly smaller periapical lesions compared with all other groups (p < 0.01). *p < 0.05. White boxes, SCID mice with T. denticola infection (n = 10; T = 4.555; 0.307 ± 0.132) (n, number of animals; T, variability; mean ± standard deviation). Grey boxes, SCID mice with red complex (RC) infection (n = 9; T = 8.492; 0.203 ± 0.073); checkered boxes, WT mice with T. denticola infection (n = 8; T = 9.58; 0.253 ± 0.091); black boxes, WT mice with RC infection (n = 10; T = 13.67; 0.192 ± 0.045). Sham control (n = 2; T = 7248; 0.115 ± 0.002).
