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Figure 1. Effects of clodronate on prostaglandin E₂ (PGE₂) (A), interleukin 1ß (IL-1ß) (B), and nitric oxide (NO) (C) production in periodontal ligament cells induced by compressive mechanical stress. Each column and bar represent the mean ± SEM (n = 3). *Significant increase vs. control (P < 0.05). **Significant increase vs. control (P < 0.01). P < 0.05 compared with load. P < 0.01 compared with load. CLO: clodronate (5, 25, 125 µM).

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