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Figure 4. Effects of Rho family GTPases on IL-1
-mediated transactivation of NF-
B and AP-1. (A) IL-1-induced NF-B and AP-1 promoter activity of the transient transfectants of N17Rac1 was greatly inhibited, and IL-1-induced NF-B and AP-1 promoter activities of transiently transfected cells (N17Cdc42 and N19RhoA) also were inhibited. Mock, transient transfectants of empty vector. Data represent means ± SD (n = 4). *P < 0:01 and **P < 0.001 vs. control (mock with IL-1). (B) Model depicting contributions of Rho family GTPases to NF-B and AP-1 activation by IL-1. Rho, Rho family GTPases; GG-Rho, geranylgeranylated Rho family GTPases.
