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Figure 3. Immunohistochemical micrographs of dental pulp (A,B) and periapical lesions (C,D) in unilateral sympathectomized rats. (A,B,D) From the non-sympathectomized side; (C) from the contralateral sympathectomized side. (A) Maxillary first molar, 20 days after a small pulp exposure (*), showing NPY-IR fiber sprouting in the pulp adjacent to reparative dentin formation (non-sympathectomized side). (B) Higher magnification of boxed area in (A). NPY-IR fibers are beaded and run longitudinally toward reparative dentin. (C) Numerous ED1-IR multinucleated osteoclasts (arrow) lining periapical lesions in molar subjected to 20 days of large pulp exposure (sympathectomized side). (D) Similar to (C) from the contralateral non-sympathectomized side, showing significantly fewer ED1-IR osteoclasts (arrow) lining the periapical lesion when compared with the sympathectomized side in (C). B, bone; Dn, dentin; L, periapical lesion; RD, reparative dentin. Scale bars, 50 µm. (From Haug and Heyeraas, 2003; reprinted with permission from Elsevier)
