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Figure 1. The primary protein structure of TIMPs. In each TIMP, 6 pairs of cysteines are linked to each other to form 6 disulfide bridges. The arrows indicate the junctions between the N- and the C-terminal domains of the proteins. The conserved VIRAK sequence is indicated in yellow. Reprinted from Critical Reviews in Oncology/Hematology, 49, Lambert E, Dassé E, Haye B, Petitfrère E, TIMPs as multifacial proteins, 187–198, Copyright (2004), with permission from Elsevier.
