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Figure. Immunohistochemical localization of DMBT1SAG in human healthy salivary gland tissue, tumor-surrounding tissue, and salivary gland tumors. The sections were counterstained with hematoxylin/eosin. (A) Healthy parotid tissue: DMBT1SAG is localized in the ducts. (B) Parotid tumor-surrounding tissue (ACC). DMBT1SAG is localized in the intercalated ducts (icd) and serous acini (a). (C) ACC surrounding tissue (upper right side) showing strong staining of luminal content of striated ducts next to ACC (lower left side). (D) Healthy submandibular gland tissue. Serous acini (a) and demilune cells (d) were DMBT1SAG-positive. (E) Submandibular tumor-surrounding tissue (PA). DMBT1SAG is localized in the intercalated ducts and strongly present in the luminal content (lc). (F) Healthy labial tissue. DMBT1SAG is localized in the ducts, demilune cells (d), and serous acini (a). (G) ACC. No DMBT1SAG was found in ACCs. (H,I) MEC, the mucus-producing cells, were DMBT1SAG-positive (m). The epidermoid-cell and intermediate-cell components were totally negative. Moreover, the luminal content (lc) stained strongly positive (H). (J) ATC, showing no DMBT1SAG expression. (K) ACT, a minor subset of tumor cells showing DMBT1SAG expression. (L), PA. DMBT1SAG staining strongly positive in the secretory product and focally some tumor cells surrounding the secretory product.
