J Dent Res 83(5): 439, 2004
© 2004 International and American Associations for Dental Research
ERRATUM
Abstract #151 on page C-60 of the Divisional Abstracts of the JDR (Vol. 82, Spec Iss C, 2003) is an inadvertent duplicate of Abstract #35 in that same group. The correct Abstract #151 appears below. The Argentine Division regrets this error.
151 Bone Biomechanics In Rats With Pharmacologically-Induced Hemolytic State. IF META*, MI OLIVERA, MI CONTI, CE LEZON, MP MARTINEZ, CE BOZZINI, RM ALIPPI. Department of Physiology. Faculty of Odontology. University of Buenos Aires, Argentina.
Structural and material biomechanical properties of bone are affected by a variety of exogenous factors. In a rat model with hemolytic state we have previously found a diminution of the diaphyseal cortical width and expansion of the marrow space, probably associated to the increased erythropoietic rate. The purpose of this study was to evaluate structural, geometrical and material mechanical propereties of the cortical diaphyseal femoral bone in immature female Sprague-Dawley rats with hemolytic state induced by the hemolytic drug phenylhidrazine (PHZ, 60 mg/kg, 2/wk x 6 wks). Treatment induced a marked reticulocytosis which was accompanied by increased splenic and erythrocyte radioiron uptake, which are expression of increased erythropoiesis. Treatment did not alter neither body growth rate nor food intake. Bone mechanical properties were tested by the 3-point bending test in an Instron 4442 apparatus. Treatment reduced the "load capacity" properties (stiffness, ultimate load, elastic limit). Cross-sectional parameters were higher and the wall/lumen ratio was lower in PHZ than in C rats. The cross-sectional moment of inertia was not altered by treatment. For both the stress and the cortical elastic modulus, the PHZ rats were lower than C rats. **The reduced mechanical competence observed in rats with PHZ-induced hemolytic state could be the consequence of a qualitative impairment of the cortical tissue.
BONE BIOMECHANICS-HEMOLYTIC STATE-ERYTHROPOIESIS.
This work was supported by the Research Grant UBACYT O-010 from the University of Buenos Aires.
