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Figure 3. Immunolocalization of WNT3 or CTNNB1 in oral carcinoma tissue. (A) WNT3 was localized to carcinoma cells at the invasive front. (B) Endothelial cells (small arrow), fibroblast-like cells (arrowhead), and macrophage-like cells (large arrow) adjacent to carcinoma cells were also positively stained. (C) Normal gingiva did not react to WNT3 antibody. (D,E) CTNNB1 stained cell-cell junction of carcinoma cells. (F,G) At the extremity of carcinoma invasion, CTNNB1 showed diffuse cytoplasmic or nuclear staining. Bar = 100 µm (A,C–E) and 50 µm (B,F,G).
