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Figure 2. Cross-sectional areas of mouse mandibular first molar tooth cellular cementum. These measurements are for mesial and distal lingual roots of three lines of mice genetically engineered to produce alterations in the growth hormone (GH) axis. (A) Bovine GH (MT-bGH) mice, with either giant mutant (GHXs) or wild-type (Wt) phenotype (both roots, n = 10). (B) Antagonist MT-bGH (bGH-G119K) mice, with either dwarf mutant (GHAnt) or Wt phenotype (both roots, n = 10). (C) GH receptor-deleted (GHR-KO) mice have three animal groups: Wt mice (mesial roots, n = 10; distal roots, n = 8); heterozygous (Het) mice (mesial roots, n = 8; distal roots, n = 9), and homozygous (KO) mice (mesial roots, n = 8; distal roots, n = 7). The areas were quantified by morphometric analysis of images of stained sections of mouse molar teeth by comparison with images of a 2.00-mm scalar. All mice were 45 days old. All areas are presented as mean ± 2SEM in mm2. ***p < 0.001, one-way ANOVA.
