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Figure 4. Electron-microscopic sections of the specimen from the experimental group at 2 wks. (A) Cells attached to the collagen sheet display spindle-shaped fibroblastic morphology. They showed spindle-shaped figures and produced collagen fiber (c). The cells contain abundant rough endoplasmic reticulum (r), numerous mitochondria (m), vacuoles (v), and lipid droplets (arrowhead). (B) Osteoblast-like cells are in close contact with newly formed bone. The cells contain rER (r), some dilated rER (d), and many mitochondria (m). New collagen fibers (c) are observed in the bone matrix.