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Figure 4. Temporal changes in the OVD, skeletal, and crown length in naïve controls, bite-raised controls, and bite-raised MesV-lesioned animals. (A) Temporal changes in the OVD measured as the length between V and T. (B) Developmental changes of the anteroposterior length of the cranium measured as the length between A and Po. (C) Temporal changes in the crown length measured as the length between Mu and Ml. The arrows indicate the day of removal of the appliance. *P < 0.05 compared with naïve controls. **P < 0.01 compared with naïve controls. +P < 0.05 compared with bite-raised controls. ++P < 0.01 compared with bite-raised controls. Bars on the symbols indicate SEM, and values on symbols in (A) indicate the number of animals.