Figure 3. Effect of guanethidine treatment on capsaicin-evoked release of iCGRP from superfused dental pulp. Pulpal tissue was treated with vehicle or phentolamine 10 µM for 7 min, and then either vehicle or guanethidine, 100 µM, was administered for an additional 21 min before stimulation with capsaicin (10 µM). Levels of iCGRP were measured as described in the legend to Fig. 1. Error bars are SEM. **p < 0.01 vs. both other groups. N = 4–5/group.

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