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Figure 3. Activation of FiRE during wound healing. (A) FiRE activation by X-Gal staining in a mucosal wound and (B) in a cutaneous wound during the proliferation phase. (C) FiRE is not detected in the mucosal wound during the remodeling phase, but (D) FiRE activity remains in the remodeling cutaneous wound. (E) PCNA immunohistochemical (brown) and FiRE X-Gal (blue) double-staining showing that FiRE is activated in migrating but not proliferating cells in the mucosal wound and (F) in the cutaneous wound. * = wound site.
