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Figure 4. The monomer BFDGE, its metabolite BFDPE-4OH, and the hydroxylated metabolite BADPE-4OH did not stimulate MCF-7 cell proliferation. Estrogen-dependent cell proliferation was evaluated as total DNA per well. The half-maximal stimulation of cell proliferation by bisphenol A (BPA) was 150 nM. Values are expressed as percent of response between solvent control (approximately 0.55 µg DNA per well) and maximal response by estradiol (E2) at 0.1 nM (approximately 1.67 µg DNA per well).
