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Figure 1. Transmission of D18S64 alleles in three families, each with two offspring who underwent orthodontic treatment. (Panel A) Pedigree. Circles denote females, squares denote males, and the 1, 2, 3, and 7 alleles within indicate the D18S64 genotype. Roman numeral (I) denotes parents and (II) denotes offspring. Arabic numbers below indicate the individual number. External apical root resorption (EARR) values, in millimeters, for the maxillary central incisors in treated offspring are shown. (Panel B) Polyacrylamide gel electrophoresis of PCR products derived from all individuals in the pedigrees. Each lane corresponds to the individual in the pedigree shown above in panel A. Band sizes in basepairs (bp) are indicated on the left (188 bp = allele 1, 190 bp = allele 2, 192pb = allele 3, and 206 bp = allele 7). (Panel C) Pre-treatment (Pre) and post-treatment (Post) lateral cephalograms for treated siblings (AII-3 and AII-4) in Family A. Apices of the roots of the central incisors and the incisal edges are indicated with upper and lower arrows, respectively.
