Figure 3. Differential pulpal blood flow (PBF) changes induced by bipolar electrical stimulation (10 sec, 50 µA, 2 ms, 20 Hz) of 1 rat mandibular incisor after systemic administration of metabotropic GluRs antagonists. (A) Amplitude and duration of initial pulpal neurogenic blood flow decrease. (B) Amplitude and duration of late pulpal neurogenic blood flow increase. 
Control group, 
MCPG 2.2 mg/kg group, 
MCPG 7.5 mg/kg group, 
MPPG 0.15 mg/kg group, 
MPPG 2.18 mg/kg group. Control rats were injected i.v. with 200 µL of a mix of 1M NaOH (105 µL/kg) and physiological saline (vehicle). Amplitude is expressed in percentage of variation of differential PBF from baseline level (difference between stimulated and control teeth). Duration is expressed in sec. Values are means ± SEM. Differences among experimental groups were evaluated by one-way ANOVA; **indicates differences that were significant for both amplitude and duration of initial blood flow decrease for animals injected with MCPG 7.5 mg/kg compared with vehicle-treated animals (p < 0.05, n = 5). For the late blood flow increase, no statistical differences were found among groups.
