Figure 4. Protein kinase C inhibitors, but not protein kinase A inhibitor, induced qualitatively similar increases in [Ca²⁺]_c in rat submandibular acinar cells. Fura-2-loaded cells were stimulated with 10 µM carbachol, and perfusate Ca²⁺ was removed. Cells were then treated with 1 µM K252a (n = 3; A), 25 µM chelerythrine (n = 3; B), 400 µM H-7 (n = 3; C), 500 nM calphostin C (n = 5; D), and 1 µM H-89 (n = 4; E) at the times indicated by the bars.

Return to article