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Inhibition of SFRP1 Reduces Severity of Periodontitis

Department of Periodontology & Oral Biology, Goldman School of Dental Medicine, Boston University, 650 Albany Street, X-343, Boston, MA 02118, USA

View larger version (105K): [in this window] [in a new window]   Figure 1. Alveolar bone loss and SFRP1 expression in the P. gingivalis-induced murine periodontitis model. (A) Morphometric images for alveolar bone loss on day 10 in the control and the infected animals. (B–D) Quantification of SFRP1-immunopositive cells identified by immunohistochemical staining: (B) inflammatory cells, (C) fibroblasts, and (D) bone-lining cells. Data represent mean values ± SEM (N = 6 for the control group, N = 5 for the infected group at each time-point). *Statistically significant at p < 0.05 by Student’s t test.

View larger version (10K): [in this window] [in a new window]   Figure 2. Apoptosis of cell types in P. gingivalis-induced murine model. (A) Inflammatory cells, (B) fibroblasts, and (C) bone-lining cells were analyzed and quantified, then represented as percentages of apoptotic cells relative to the total cell counts in the same field of analysis by TUNEL assay. Data represent mean values ± SEM (N = 6 for the control group, N = 5 for the infected group at each time-point). *,, and = statistically significant at p < 0.05, p < 0.01, and p < 0.001, respectively.

View larger version (97K): [in this window] [in a new window]   Figure 3. Localized treatment with anti-SFRP1 antibody reduced alveolar bone loss in the P. gingivalis-induced periodontitis model. Representative macroscopic image of alveolar bone after de-fleshing viewed from the palatal side on day 10. Animals were treated with either IgG or anti-SFRP1 antibody.