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Delivery Mode and Efficacy of BMP-2 in Association with Implants

¹ ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland;
² ACTA, Section of Oral Implantology and Prosthetic Dentistry, Department of Oral Function, Amsterdam, The Netherlands;
³ Department of Science and Technology, University of Twente, The Netherlands; and
⁴ Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Switzerland

View larger version (6K): [in this window] [in a new window]   Figure 1A. Bone formation in association with coatings bearing adsorbed BMP-2, expressed as a function of time and the amount of BMP-2 adsorbed. Mean values ± SEM (n = 6) are represented.

View larger version (9K): [in this window] [in a new window]   Figure 1B. Bone formation in association with coatings bearing incorporated BMP-2, 2 and 5 wks after implantation, expressed as a function of the amount of BMP-2 incorporated. Mean values ± SEM (n = 6) are represented. *P < 0.001.

View larger version (9K): [in this window] [in a new window]   Figure 2A. Bone formation in association with coatings bearing different amounts of incorporated BMP-2 and a fixed dose of adsorbed BMP-2 (7.5 µg per implant), 2 wks after implantation, expressed as a function of the incorporated dose of BMP-2. Mean values ± SEM (n = 6) are represented. *P < 0.05; **P < 0.001.

View larger version (10K): [in this window] [in a new window]   Figure 2B. Coating degradation in the various experimental groups, 2 wks after implantation.

View larger version (63K): [in this window] [in a new window]   Figure 3. Light micrographs of titanium-alloy discs 2 weeks after implantation. (A) Low-magnification light micrograph of an implanted titanium-alloy disc (Ti) bearing a layer of calcium phosphate (C) into which BMP-2 has been incorporated. At this two-week juncture, the disc is surrounded by a growing mass of woven bone (B). (B) High-magnification view of the specimen illustrated in Fig. 3A. The coating (C) is being degraded by osteoclasts (arrows). This degradative activity occurs concomitantly with the deposition of woven bone (B). A = artefactual space between the coating (C) and the titanium-alloy disc (Ti), generated by shrinkage during tissue processing. (C) Low-magnification light micrograph of a naked (uncoated) titanium-alloy disc (Ti) bearing no BMP-2, 2 wks after implantation. The disc is surrounded by a connective tissue capsule (S) from which it has become artefactually separated (arrows) during tissue processing. No bone formation has occurred.