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Treponema denticola in Disseminating Endodontic Infections

¹ Department of Cytokine Biology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA;
² Endodontics Unit, Department of Oral Sciences, University of Bologna, Italy;
³ Department of Molecular Genetics, The Forsyth Institute, Boston, MA, USA;
⁴ Section of Microbiology, DMCSS, Ospedale S. Orsola, University of Bologna, Italy; and
⁵ Institute for Biomedical Engineering, ETH, and University of Zürich, Switzerland

View larger version (25K): [in a new window]   Figure 1. Effect of endodontic infection on body weight in immunocompetent and immunodeficient mice on day 0 and day 21 after infection. SCID mice infected with T. denticola showed a significant decrease of body weight from days 0 to 21. *p < 0.01. White boxes, SCID mice with T. denticola infection (n = 10; T = 8.03; 21.78 ± 1.52; 19.20 ± 1.04) (n, number of animals; T, variability, mean ± standard deviation @ day 0; mean ± standard deviation @ day 21); checkered boxes, SCID mice with red complex (RC) infection (n = 9; T = 3; 21.03 ± 1.41; 19.92 ± 2.05); gray boxes, WT mice with T. denticola infection (n = 8; T = 0.36; 21.18 ± 1.44; 21.82 ± 1.56); black boxes, WT mice with RC infection (n = 10; T = 0.74; 21.50 ± 1.46; 21.66 ± 1.80).

View larger version (61K): [in a new window]   Figure 2. Periapical bone resorption caused by endodontic infection. (A) Micro CT image showing the pivot section of a mandibular first left molar and the area of resorption (outlined in white). (B) Comparison of areas (expressed in mm2) of periapical bone resorption in the different experimental groups. SCID animals infected with T. denticola showed periapical lesions of greater size compared with those in SCID and WT animals infected with red complex (p < 0.05). Sham controls presented significantly smaller periapical lesions compared with all other groups (p < 0.01). *p < 0.05. White boxes, SCID mice with T. denticola infection (n = 10; T = 4.555; 0.307 ± 0.132) (n, number of animals; T, variability; mean ± standard deviation). Grey boxes, SCID mice with red complex (RC) infection (n = 9; T = 8.492; 0.203 ± 0.073); checkered boxes, WT mice with T. denticola infection (n = 8; T = 9.58; 0.253 ± 0.091); black boxes, WT mice with RC infection (n = 10; T = 13.67; 0.192 ± 0.045). Sham control (n = 2; T = 7248; 0.115 ± 0.002).