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Clodronate Inhibits PGE₂ Production in Compressed Periodontal Ligament Cells

¹ Divisions of Orthodontics and Dentofacial Orthopedics,
² Oral Dysfunction Science, and
³ Dental Pharmacology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan

View larger version (15K): [in a new window]   Figure 1. Effects of clodronate on prostaglandin E2 (PGE2) (A), interleukin 1ß (IL-1ß) (B), and nitric oxide (NO) (C) production in periodontal ligament cells induced by compressive mechanical stress. Each column and bar represent the mean ± SEM (n = 3). *Significant increase vs. control (P < 0.05). **Significant increase vs. control (P < 0.01). P < 0.05 compared with load. P < 0.01 compared with load. CLO: clodronate (5, 25, 125 µM).

View larger version (58K): [in a new window]   Figure 2. Effect of clodronate on gene expression for cyclo-oxygenase-2 (COX-2) and receptor activator nuclear factor B ligand (RANKL) in compressed periodontal ligament cells. (A) RT-PCR for COX-2, RANKL, and ß-actin. CLO: 125 µM. (B) Relative expression of RANKL mRNA and COX-2 mRNA determined by densitometric analysis. Values were corrected for ß-actin mRNA expression. Representative results of 1 of 3 independent experiments are shown. CLO: clodronate (5, 25, 125 µM).