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Omega-3 Fatty Acid Effect on Alveolar Bone Loss in Rats

¹ Center for Oral Health Research, College of Dentistry, 159 HSRB, University of Kentucky, Lexington, KY 40536-0305, USA; and
² Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

View larger version (16K): [in a new window]   Figure 1. Schematic diagram illustrating experimental design, fish and corn oil diet feeding, P. gingivalis infections, plaque sample collection, PCR analysis, death, gingival tissue, and alveolar bone collection (detailed information in MATERIALS & METHODS).

View larger version (20K): [in a new window]   Figure 2. Effects of n-3 PUFA (FO) and corn oil (CO) diets on P. gingivalis 381 and A7A1-28-infection and induced IgG antibody levels in rats. Infected/total denotes number of rats positive for P. gingivalis infection by PCR, compared with total number of rats in the experimental group. Each bar represents the mean serum IgG antibody levels of 13–21 rats per group, and the vertical bars denote 1 standard deviation from the mean. Homologous denotes antibody responses in the rats to the identical infecting strain, and X-reactive denotes antibody levels to the heterologous P. gingivalis strain. IgG antibody levels in all infected groups were significantly greater than control uninfected rats (p < 0.001).