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Extracellular Phosphate Alters Cementoblast Gene Expression

R.B. Rutherford1,*, B.L. Foster2, T. Bammler3, R.P. Beyer3, S. Sato2, and M.J. Somerman2

1 Department of Oral Biology, School of Dentistry, University of Washington, Box 357132, Seattle, WA 98195-7132, USA;
2 Department of Periodontics, School of Dentistry, University of Washington; and
3 Department of Environmental & Occupational Health Sciences, School of Medicine, University of Washington


Figure 1
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  		Figure 1. The fold change in expression of selected transcription factors from the total transcription factor GO Group altered by exposure of cementoblasts to 5 mM ePi is displayed. Values are the average of triplicate arrays and differ from controls, p ≤ 0.05.

 

Figure 2
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  		Figure 2. The fold change in expression of selected transcription factors from the total Wnt signaling GO Group altered by exposure of cementoblasts to 5 mM ePi is displayed. Values are the average of triplicate arrays and differ from controls, p ≤ 0.05.

 

Figure 3
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  		Figure 3. Speculative schematic depicting some known functions of genes whose expression was affected by ePi by 24 hrs. ePi resulted in differential patterns of expression of genes mediating Wnt signaling, suggesting a complex role for these genes in ePi signaling. The expression of Bmp4 and osterix (Sp7), implicated in bone and tooth development, as well as an inhibitor of Bmp Tob1, appears to be co-regulated, so that BMP signaling is diminished. The transcription factors Foxc2, a stimulator of chondroblast differentiation, and Egr2, a promoter of mineralization, may play a similar role in cementoblasts.

 




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