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Figure 2. Stacked-bar histogram of caries scores, according to tooth surface category, for the two experiments lasting 42 days post-inoculation with designated S. mutans strains. In the first experiment (panels A and B), there were 12 rats per group; in the second experiment (panels C and D), there were 10 rats per group. Mean ± SEM values are represented for each tooth surface category identified by bar shades, and the height of each stacked bar represents mean total caries score and its variance (SEM), indicated to its immediate right. Panels A and C depict the data for enamel (Keyes E) lesions, and panels B and D depict the data for dentinal (Keyes Dm) lesions, respectively. The scoring method of Keyes does not assess dentinal penetration on rat morsal tooth surfaces. The experimental design and blinded caries scoring methods are detailed in the text. The use of data pooled from the two experiments * indicates a statistically significant difference of the fruCD mutant-infected group for enamel caries scores by comparison with those of the wild-type UA159-infected group. indicates statistically significant differences of the fruI mutant-infected group for dentin scores by comparison with their respective wild-type UA159-infected and gtfA-infected group, as detailed in the RESULTS.
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