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Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec City, Québec, Canada G1K 7P4

View larger version (20K): [in a new window]   Figure 1. Effect of treating macrophages with fraction 1 (non-dialyzable material of cranberry juice), fraction 2 (cranberry juice), and epigallocatechin gallate (EGCG) on the secretion of IL-6 (A), TNF- (B), and IL-1ß (C) induced by LPS (1 µg/mL) of A. actinomycetemcomitans ATCC 29522 for 24 hrs. Macrophages were treated with cranberry fractions, or EGCG, for 2 hrs prior to lipopolysaccharides (LPS) stimulation. Cytokine secretion was assessed by ELISA. The data are the means ± standard deviations of triplicate assays for three independent experiments. *P value of < 0.05 compared with untreated control.

View larger version (25K): [in a new window]   Figure 2. Effect of treating macrophages with fraction 1 (non-dialyzable material of cranberry juice), fraction 2 (cranberry juice), and epigallocatechin gallate (EGCG) on the secretion of IL-8 (A) and RANTES (B) induced by LPS (1 µg/mL) of A. actinomycetemcomitans ATCC 29522 for 24 hrs. Macrophages were treated with cranberry fractions, or EGCG, for 2 hrs before lipopolysaccharides (LPS) stimulation. Cytokine secretion was assessed by ELISA. The data are the means ± standard deviations of triplicate assays for three independent experiments. *P value of < 0.05 compared with untreated control.