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Articaine is More Effective than Lidocaine or Mepivacaine in Rat Sensory Nerve Conduction Block in vitro

I. Potonik^1,*, M. Tomi², J. Sketelj³, and F.F. Bajrovi³

¹ Department of Restorative Dentistry & Endodontics, University of Ljubljana, Dental School, Hrvatski trg 6,1000 Ljubljana, Slovenia;
² Institut Jozef Stefan, Ljubljana; and
³ Institute of Pathophysiology, Medical Faculty, University of Ljubljana

View larger version (12K): [in a new window]   Figure 1. Registration of the Compound Action Potential (CAP) of the isolated sural nerve (SN) in a liquid paraffin bath. Local anesthetic solution (LA) was injected into the silicone tube (ST), which had been cut longitudinally and placed between the stimulating (S) and recording (R) electrodes.

View larger version (10K): [in a new window]   Figure 2. The Compound Action Potential (CAP) of A-fibers (a) and C-fibers (b) of the rat sural nerve before nerve block induction. The voltage and duration (intensity) of the supramaximal electrical stimulus were about 10 V-10 µsec for the A-fiber signal and about 12 V-1 msec for the C- fiber signal.

View larger version (16K): [in a new window]   Figure 3. The amplitude of the CAPs (a) and conduction velocities (b) of rat sural nerve (mean ± SD) A-fibers before (black bars) and after (white bars) nerve block induction with 2% (n = 8) and 4% (n = 9) lidocaine (L), 3% (n = 10) mepivacaine (M), and 2% (n = 9) and 4% (n = 8) articaine (A).