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Tissue pH and Temperature Regulate Pulpal Nociceptors

¹ Division of Endodontics, Department of Preventive and Restorative Sciences, UCSF, 707 Parnasssus Ave., San Francisco, CA 94143, USA; and
² Department of Endodontics and
³ Department of Pharmacology, UTHSCSA, San Antonio, TX, USA

View larger version (9K): [in a new window]   Figure 1. Effect of administration of capsaicin to the dental pulp at a pH of 7.4 and 6.5. Capsaicin evoked a significant increase in CGRP over basal rates of release: 9.5 fmmol/2.1 mL at a pH of 6.5 and 6.5 fmol/2.1 mL at a pH of 7.4. Recovery 1, 2, and 3 indicate successive fractions after capsaicin stimulation. While fractions continued to be collected, data (not shown) dictated that levels returned to baseline.

View larger version (9K): [in a new window]   Figure 2. Percent increase in immunoreactive CGRP (iCGRP) over basal rates at a pH of 7.4 and 6.5 and temperatures of 37°C and 26°C. There was a 140% increase in iCGRP release with CAP/pH 6.5.